Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Adverse effects of brimonidine eye drop in children: A case series

(2021) Adverse effects of brimonidine eye drop in children: A case series. J Clin Pharm Ther.

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Official URL: https://pubmed.ncbi.nlm.nih.gov/33626597/

Abstract

WHAT IS KNOWN AND OBJECTIVE: Brimonidine is increasingly used in the treatment of intraocular hypertension. CASE SUMMARY: We report on five paediatric patients suffering from brimonidine eye drop intoxication. The most frequent signs of the intoxication were a lowered level of consciousness and hypotonia. Other complications were apnea, bradycardia, hypotension and seizure. One of the patients needed cardiopulmonary resuscitation. Apnea in one of the cases was resistant to naloxone. Pupils were unremarkable in two cases. WHAT IS NEW AND CONCLUSION: Brimonidine is potentially lethal for young infants. The absence of miosis and absence of response to naloxone is not a reason to rule out brimonidine poisoning.

Item Type: Article
Keywords: adrenergic alpha2-Agonists adverse effects brimonidine tartrate children critical care poisoning
Subjects: WW Ophthalmology > WW 505-525 Occupational Ophthalmology. Eye Injuries
pediatric
Depositing User: هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/7632

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