Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

The antioxidant curcumin postpones ovarian aging in young and middle-aged mice

(2020) The antioxidant curcumin postpones ovarian aging in young and middle-aged mice. Reproduction Fertility and Development.

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Reproductive senescence is accompanied by a reduced number and quality of ovarian follicles in response to the accumulation of free radicals and the process of apoptosis. Having selected mice as models, we examined the hypothesis that curcumin as an antioxidant and anti-inflammatory agent might prevent or retard ovarian aging. Female NMRI 21-day-old mice were divided into control, vehicle and curcumin groups. In the treatment group the mice received curcumin at 100 mg kg(-1) day(-1) intraperitoneally. After 6, 12 and 33 weeks several parameters were examined including ovarian reserve, oocyte quality, oxidative status, in vitro fertilisation and expression of ovulation-related (growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15)) and anti-aging-related (sirtuin 1 (SIRT-1) and SIRT-3) genes. Curcumin treatment up to 12 and 33 weeks resulted in increased ovarian volume and number of follicles and was associated with elevated anti-Mullerian hormone and oestrogen and diminished FSH serum levels. Furthermore, enhanced oocyte maturation, fertilisation and embryo development plus reduced oxidative stress were seen in the curcumin group. Also, the expression of GDF-9, BMP-15, SIRT-1 and SIRT-3 genes was increased in the curcumin group. Concerning gestational age, the findings of the study suggested that administration of curcumin could delay the process of oocyte aging in a mouse model.

Item Type: Article
Keywords: in vitro fertilisation ovarian reserve oxidative stress glutathione in-vitro follicles methoxychlor expression protects oocytes atresia fluid cell Developmental Biology Reproductive Biology Zoology
Subjects: WP Gynecology and Obstetrics > WP 400-480 Uterus. Cervix
Divisions: Research Vice-Chancellor Department > Fertility and Infertility Research Center
Depositing User: هدی فهیم پور

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