Repository of Research and Investigative Information

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Hormozgan University of Medical Sciences

Antioxidant, cytotoxic and catalytic degradation efficiency of controllable phyto-synthesised silver nanoparticles with high stability using Cordia myxa extract

(2019) Antioxidant, cytotoxic and catalytic degradation efficiency of controllable phyto-synthesised silver nanoparticles with high stability using Cordia myxa extract. Journal of Experimental Nanoscience.

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Abstract

This study aimed to report a one-pot, eco-friendly and room temperature procedure to prepare highly stable (at least 15 months) silver nanoparticles (AgNPs) using the aqueous leaf extract of Cordia myxa. The effects of different parameters, such as applied pH in the reaction mixture, amount of the leaf extract, silver ion concentrations, time of reaction and synthesis temperature, on the formation of NPs and their Surface Plasmon Resonance (SPR) spectra were studied. The characterisation of the prepared AgNPs was done using UV-Vis spectroscopy, Fourier Transform Infrared (FTIR), X-Ray Differentiation (XRD) and Transmission Electron Microscope (TEM) techniques. The shape of the synthesised AgNPs was spherical and it sized 3–10 nm with a face-centred cubic structure with SPR spectra at 410 nm. A possible reaction mechanism of AgNP formation by biomolecules of C. myxa was also introduced. The efficiency of the synthesised AgNPs as an excellent catalyst for the reduction of organic azo dyes using NaBH4 was proved. Dose-dependent cytotoxic activity of the prepared AgNPs against SW480 and HCT116 human colon cancer cell lines was also shown using MTT assay. Furthermore, the Ferric-Reducing Antioxidant Power (FRAP) assay was utilised to confirm the antioxidant activity of NPs. Non-toxic reagents and low-cost synthesis were the main features that made these AgNPs more attractive for chemical/biomedical applications. © 2019, © 2019 The Author(s). Published by Taylor & Francis Group on behalf of the Academy of Forensic Science.

Item Type: Article
Additional Information: cited By 0
Keywords: Antioxidants; Azo dyes; Catalyst activity; Cell culture; Degradation; Efficiency; Fourier transform infrared spectroscopy; Metal ions; Metal nanoparticles; Silver nanoparticles; Sodium Borohydride; Surface plasmon resonance; Synthesis (chemical); Transmission electron microscopy; Ultraviolet visible spectroscopy, Anti-oxidant activities; Catalytic degradation; Cytotoxic activities; Green synthesis; Leaf extracts, Tungsten compounds, azo dye; Cordia myxa extract; methylene blue; reactive oxygen metabolite; rhodamine B; silver nanoparticle; silver nitrate; sodium borohydride, antioxidant activity; aqueous solution; Article; Boraginaceae; catalytic efficiency; cell viability; concentration (parameter); controlled study; Cordia myxa; degradation; dispersity; drug cytotoxicity; ferric reducing antioxidant power assay; Fourier transform infrared spectroscopy; HCT 116 cell line; human; human cell; hydrodynamics; molecular stability; MTT assay; nanocatalysis; nanocatalyst; one pot synthesis; particle size; pH; photon correlation spectroscopy; plant leaf; priority journal; reaction analysis; reaction temperature; reaction time; room temperature; surface plasmon resonance; SW480 cell line; transmission electron microscopy; ultraviolet visible spectrophotometry; ultraviolet visible spectroscopy; X ray diffraction
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 100-133 Biochemistry of the Human Body
QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Divisions: Research Vice-Chancellor Department > Molecular Medicine Research Center
Depositing User: هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/6722

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