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Hormozgan University of Medical Sciences

Effect of Continuous Endurance Training on mRNA Expression of Interferon Gamma and Matrix Metalloproteinase-9 in Male Elder Rats

(2018) Effect of Continuous Endurance Training on mRNA Expression of Interferon Gamma and Matrix Metalloproteinase-9 in Male Elder Rats. Hormozgan Medical Journal.

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Abstract

Background: Aging impairs function of the heart and is associated with mechanical remodeling. This process involves accumulation of collagen and dysfunction in the regulation of active matrix metalloproteinase. On the other hand, exercise training improves cardiac function and regulates the increase of pro-inflammatory molecules, such as interferon gamma, yet the impact of exercise training on aging has not yet been defined. Objectives: This study examined the effect of continuous endurance training on mRNA expression of interferon gamma (IFN-γ) and matrix metalloproteinase-9 (MMP-9) in male elder rats. Methods: For this purpose, 14 Wistar male rats with age of 24 to 26 months and an average weight of 380 ± 20 g were randomly divided to two groups, including training (n = 7) and control (n = 7). Training groups performed continuous endurance training for six weeks. Matrix metalloproteinase-9 mRNA and interferon (IFN)-γ mRNA expression in heart tissue were measured by real-time polymerase chain reaction. To analyze of the data, the independent t-test was used at a significance level of P < 0.05. Results: The findings of this statistical analysis showed that six weeks of continuous endurance training had a significant effect on MMP-9 mRNA expression (P = 0.001). Also, this training protocol did not have a significant effect on expression of IFN-γ gene (P = 0.628). Conclusions: Continuous endurance training attenuated aging-induced cardiac inflammation of rats. There are numerous questions that remain to be answered to complete the understanding of the moderator effects of exercise on MMP-9 and IFN-γ, as a muscle conformity or indicate an inflammatory condition.

Item Type: Article
Keywords: Endurance-Continuous Training; Interferon-Gamma; Matrix Metalloproteinase-9; Elder Rats
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Divisions: Research Vice-Chancellor Department > Hormozgan Medical Journal
Depositing User: هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/6269

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