Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

MiRNAs and inflammatory bowel disease: An interesting new story.

(2019) MiRNAs and inflammatory bowel disease: An interesting new story. J Cell Physiol.

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/30417350

Abstract

Inflammatory bowel disease (IBD), as a chronic and recurrent inflammatory disorder, is caused by a dysregulated and aberrant immune response to exposed environmental factors in genetically susceptible individuals. Despite huge efforts in determining the molecular pathogenesis of IBD, an increasing worldwide incidence of IBD has been reported. MicroRNAs (miRNAs) are a set of noncoding RNA molecules that are about 22 nucleotides long, and these molecules are involved in the regulation of the gene expression. By clarifying the important role of miRNAs in a number of diseases, their role was also considered in IBD; numerous studies have been performed on this topic. In this review, we attempt to summarize a number of studies and discuss some of the recent developments in the roles of miRNAs in the pathophysiology, diagnosis, and treatment of IBD.

Item Type: Article
Keywords: apoptosis; autophagy; inflammation; inflammatory bowel disease; microRNA
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
WI Digestive System > WI 400-575 Intestines
Depositing User: هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/6161

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