Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

FoxP3 gene polymorphism is associated with breast cancer in Iranian patients

(2018) FoxP3 gene polymorphism is associated with breast cancer in Iranian patients. Exp Oncol.

[img] Text
2479.pdf

Download (246kB)

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/30593749

Abstract

AIM: Breast cancer (BC) is one of the leading causes of cancer death among women. Recent studies have characterized FoxP3 as a marker of regulatory T cells and an X-linked tumor suppressor gene, which is involved in the pathogenesis of BC. Therefore, we investigated the potential influence of three single-nucleotide polymorphisms (SNPs) of FoxP3 gene on the development of BC in Iranian women. MATERIALS AND METHODS: The association between FoxP3 rs2232365, rs3761548 and rs4824747 polymorphisms and BC risk was assessed in 124 BC patients and 198 healthy controls using sequence-specific primers. RESULTS: We identified significant difference of rs3761548 in both allele and genotype frequencies between cases and control groups. Our results showed that individuals carrying FoxP3 rs3761548 AA genotype had about 4.3-fold increased risk of BC compared with CC carriers. No significant association was found between rs3761548C>A polymorphism and clinical outcome parameters (age of onset, tumor size, lymph nodes metastasis, tumor stage, progesterone receptor status, estrogen receptor status, Ki-67 status, HER-2 status and duration of disease). CONCLUSION: This study has provided the first genetic data on the FoxP3 gene polymorphism in south of Iran and proposes the rs3761548 polymorphism of FoxP3 gene as a risk factor, but not a prognostic marker in the development of BC in Iranian population.

Item Type: Article
Keywords: breast cancer, FoxP3, polymorphism, Treg cells.
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
QZ Pathology > QZ 200-380 Neoplasms
WP Gynecology and Obstetrics > WP 800-910 Breast
Depositing User: هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/6149

Actions (login required)

View Item View Item