Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

The association of gastritis and peptic ulcer with poly morphisms in the inflammatory-related genes IL-4 and IL-10 in Iranian population

(2018) The association of gastritis and peptic ulcer with poly morphisms in the inflammatory-related genes IL-4 and IL-10 in Iranian population. Iranian Journal of Pathology.

[img] Text
article_31702_6d81dded44891b7c41e73a90938e4c8d.pdf

Download (835B)

Official URL: http://ijp.iranpath.org/article_31702_3969.html

Abstract

Background & Objective: The current study aimed at assessing the relationship between gastritis and peptic ulcer susceptibility and inflammation-related gene polymorphisms in Iranian patients.Gastritis and peptic ulcer are common medical complications with serious outcomes on the quality of life. Inflammatory responses of gastric mucosa are associated with helicobacter pylori, but most infected patients remain as-ymptomatic. There is strong evidence that inflammatory response is a major part of its etiology. Methods: The current case-control study aimed atexamining genetic polymorphisms in inflammatory cytokines interleukin (IL)-4, and IL-10 using polymerase chain reaction-variable number tandem reaped (PCR-VNTR) and PCR-restriction fragment length polymorphism(RFLP) methods, respectively in 603 genotyped patients admitted to Mohammadi Hospital in Bandar Abbas, Iran(198 patients with gastritis, 84 with peptic ulcer, and 321 patients as controls). Results: No significant associations were detected in genotype and allele frequencies of IL-10 and IL-4 between the case (with gastritis and peptic ulcer) and control groups. Conclusion: In conclusion, the results of the analyses suggested that these poly morphisms may not predispose the carriers to gastritis and peptic ulcer development.

Item Type: Article
Keywords: Gastritis Interleukin Peptic ulcer Poly morphism
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
QZ Pathology > QZ 40-105 Pathogenesis. Etiology
Divisions: Education Vice-Chancellor Department > Faculty of Dental > Department of Oral and Maxillofacial Pathology
Depositing User: هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/6128

Actions (login required)

View Item View Item