Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Relationship of SNP rs2645429 in Farnesyl- Diphosphate Farnesyl-transferase 1 Gene Promoter with Susceptibility to Lung Cancer

(2018) Relationship of SNP rs2645429 in Farnesyl- Diphosphate Farnesyl-transferase 1 Gene Promoter with Susceptibility to Lung Cancer. INTERNATIONAL JOURNAL OF GENOMICS.

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Abstract

Background and Purpose. The mevalonate pathway is one of the major metabolic pathways that use acetyl-CoA to produce sterols and isoprenoids. These compounds can be effective in the growth and development of tumors. One of the enzymes involved in the mevalonate pathway is FDFT1. Different variants of this gene are involved in the risk of suffering various diseases. The present study examined the relationship between FDFT1 rs2645429 polymorphism and the risk of nonsmall cell lung cancer (NSCLC) in a population from southern Iran. Method. The genotypes of rs2645429 polymorphism of FDFT1 gene were examined in 95 samples: 34 patients with NSCLC and 61 healthy individuals by RFLP method. Results. The results of this study indicated that C allele of this polymorphism was effectively associated with the risk of NSCLC in the Iranian population (p value = 0.023; OR = 2.71; 95% CI = 1.12-6.59) and CC genotype has significant relation with susceptibility to NSCLC (p value = 0.029; OR = 3.02; 95% CI = 1.09-8.39). This polymorphism is located in the promoter region FDFT1 gene, and CC genotype may increase the activity of this promoter. This study also found a significant relationship between C allele and metastatic status. C allele was more common in NSCLC patients. (p = 0 04). Conclusion. C allele of FDFT1 rs2645429 polymorphism gene can be a risk factor for NSCLC, whereas T allele probably has a low protective role.

Item Type: Article
Keywords: LOVASTATIN-INDUCED APOPTOSIS; MEVALONATE PATHWAY; LIPID-METABOLISM; SQUALENE SYNTHASE; BREAST-CANCER; RISK; POLYMORPHISM; CHOLESTEROL; PROGRESSION; MORTALITY
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 75-99 Carbohydrates. Lipids
QZ Pathology > QZ 200-380 Neoplasms
Divisions: Research Vice-Chancellor Department > Molecular Medicine Research Center
Depositing User: هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5941

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