Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Impaired expression of Drosha in breast cancer

(2017) Impaired expression of Drosha in breast cancer. Breast Disease,.

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Official URL: https://content.iospress.com/articles/breast-disea...

Abstract

wnregulation of the miRNAome in various types of malignancy. We previously reported that DGCR8 and Dicer genes dysregulated in patients with breast cancer. OBJECTIVE:To evaluate the expression pattern of Drosha in patients with breast cancer. METHODS:We evaluated the mRNA expression level of Drosha in 70 fresh breast carcinomas and adjacent non-neoplastic tissue using quantitative real-time PCR and assessed the possible correlation between its expression and clinicopathological parameters. RESULTS:Our results revealed that mRNA expression level of Drosha was decreased in tumors when compared to adjacent non-neoplastic tissue. However, this difference is not statistically significant (P > 0.05). Downregulation of Drosha is related to older age at diagnosis, higher histological grade, higher tumor size and metastasis. However, there was no significant correlation between Drosha expression level and clinicopathological parameters (P > 0.05). We found that Drosha expression negatively correlated with DGCR8 (P = 0.043), whereas dysregulated expression levels of Drosha and Dicer are positively correlated with to each other (P < 0.0001). CONCLUSION:This study provides evidence that the expression of Drosha is impaired in breast cancer. However, the molecular basis of observed expression pattern have remained inexplicable and should be further investigated.

Item Type: Article
Keywords: MiRNA processing machinery, Drosha, DGCR8, Dicer, breast cancer
Subjects: QZ Pathology > QZ 200-380 Neoplasms
WP Gynecology and Obstetrics > WP 800-910 Breast
Depositing User: هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5915

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