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Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

GNB3 C825T POLYMORPHISM ASSOCIATES WITH PLASMA ELECTROLYTE BALANCE AND SUSCEPTIBILITY TO HYPERTENSION

(2011) GNB3 C825T POLYMORPHISM ASSOCIATES WITH PLASMA ELECTROLYTE BALANCE AND SUSCEPTIBILITY TO HYPERTENSION. INTERNATIONAL JOURNAL OF CARDIOLOGY.

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Abstract

Objective: The role of G protein activation in cardiovascular disorders is well known. The GNB3 C825T polymorphism of the gene encoding the G-protein b3 subunit (GNB3) is associated with increased intracellular signal transduction. We aimed to investigate the role of the variant in susceptibility to hypertension and association with plasma sodium and potassium concentrations. Methods: Consecutive subjects consisting 345 healthy controls and 455 patients with essential hypertension were enrolled. Plasma renin activity and aldosterone concentration were measured. The variant was typed by SNaPshot, analyzed on ABI Prism 3100 Genetic Analyzer and ABI Prism GeneScan. Results: The TT genotype was over-represented in the patients (LRTc2 = 16.2, P < 0.001) and T allele as well (LRTc2 = 25.9, P < 0.0001). Multiple-logistic regression analysis disclosed that the risk of hypertension was significantly greater for TT genotype (P < 0.0001, OR = 6.1, Wald’s 95% CI = 2.9–12.7). One-way ANOVA revealed that hypertensive T-allele carriers (CT+TT) compared to non-carriers (CC) had a greater BMI, mean arterial pressure (MAP) and PAC (P = 0.01, P = 0.01, P < 0.0001, respectively); while the Methods: In this double-blinded randomized clinical trial, 40 patients were randomly assigned to receive either IV aminophylline (5,g/kg) (n=20) or saline (n=20) before anesthesia induction. Troponin T level was measured 30 minuets, 2 hours and 24 hours after aortic clamping. For data analysis, t-test, chi-square and Mann-Whitney test was used. Results: Troponin T level was significantly lower in aminophylline group 30 minutes (P=0.03) and 2 hours (P=0.01) after aortic cross clamp. No difference was observed with clinical Parameters. Conclusion: Pretreatment with aminophylline reduces myocardial injury at sub-clinical level, particularly to benefit the ante-retrograde cardioplegia alone. patients with 825TT risk genotype showed higher plasma sodium, serum creatinine, urea and lower potassium (P < 0.0001, each). Conclusions: Our results strongly highlight the role of GNB3 C825T polymorphism leading to an increased activity of G-protein, enhanced the Na/H exchanger and subsequently associates with higher plasma sodium, lower potassium levels, high BMI and susceptibility to hypertension.

Item Type: Article
Keywords: GNB3 C825T POLYMORPHISM ASSOCIATES WITH PLASMA ELECTROLYTE BALANCE AND SUSCEPTIBILITY TO HYPERTENSION
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5457

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