Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Association of insulin resistance with serum interleukin-6 and tnf-α levels during normal pregnancy

(2011) Association of insulin resistance with serum interleukin-6 and tnf-α levels during normal pregnancy. Biomarker Insights.

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Abstract

Overview: The purpose of this study was to evaluate the role of Tumor Necrosis Factor-α (TNF-α) in insulin resistance (IR) during normal pregnancy. Approach: This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively, and in 21 healthy non pregnant women. Serum TNF-α concentration was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Results: There were significant differences between serum TNF-α and IL-6 levels in pregnant women as compared with maternal healthy controls. There was significant correlation between gestational age and Body Mass Index (BMI) (r = 0.28, P = 0.01). There was no significant correlation between gestational age and insulin resistance (IR). We also did not find correlations between IR and TNF-α and IR and IL-6 in pregnant women. Conclusion: In conclusion, our findings suggest that TNF-α and IL-6 are not greatly contributed to pregnancy induced insulin resistance in normal pregnancy © the author(s), publisher and licensee Libertas Academica Ltd.

Item Type: Article
Additional Information: cited By 12
Keywords: interleukin 6; tumor necrosis factor alpha, adult; article; body mass; controlled study; enzyme linked immunosorbent assay; female; first trimester pregnancy; gestational age; human; insulin resistance; maternal care; pregnancy; protein blood level; protein function; second trimester pregnancy; third trimester pregnancy
Subjects: WQ Obstetrics > WQ 215-270 Pregnancy Complications
endocrine
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5399

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