Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Significance of blood-related high-risk behaviors and horizontal transmission of hepatitis B Virus in Iran

(2011) Significance of blood-related high-risk behaviors and horizontal transmission of hepatitis B Virus in Iran. Archives of Virology.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Hepatitis B virus (HBV) is a significant public health problem and a leading cause of morbidity and mortality, and approximately 30 of the world's population is infected with HBV. The objective of our study was to determine the seroprevalence of HBV and major risk factors associated with its occurrence. Four thousand eighty-seven healthy Iranian subjects aged 8-80 years were screened for HBV serological markers by an enzyme immunoassay method. A structured questionnaire was administered to all participants. Multiple logistic regression, an unpaired t-test for continuous data and the χ2 test for categorical data were performed. A total of 4087 participants were tested for hepatitis B surface antigen (HBsAg), of which 62 (1.5) were seropositive. Fifteen percent of the subjects were positive for anti-HBs, 6.3 were positive for isolated anti-HBc and 12.5 were positive for both anti-HBs and anti-HBc. Laborers showed a higher HBsAg+ seroprevalence and risk compared with jobless participants (Pearson's = 8.276, P = 0.004; OR = 4.1, 95 CI: 1.5-11.2). Bivariate logistic regression revealed that the following variables were significantly associated with HBV seropositivity: phlebotomy (P = 0.002; OR = 5.0, 95 CI: 2.1-11.9), tattooing (P = 0.003; OR = 3.4, 95 CI: 1.6-7.0), intravenous drug use (P = 0.001; OR = 2.4, 95 CI: 1.4-4.1). The adjusted prevalence ratios remained significantly associated with HBV seropositivity and thus likely served as possible risk factors for HBV. The overall positive seroprevalence was 1.5. Among the variables, only phlebotomy, tattooing and intravenous drug injection emerged as major potential risk factors for hepatitis B infection and responsible for transmission of the disease. © 2011 Springer-Verlag.

Item Type: Article
Additional Information: cited By 11
Keywords: hepatitis B core antigen; hepatitis B surface antigen, adolescent; adult; aged; article; blood; bloodborne bacterium; child; disease transmission; epidemiology; female; hepatitis B; Hepatitis B virus; high risk behavior; human; immunology; Iran; isolation and purification; male; middle aged; questionnaire; virology, Adolescent; Adult; Aged; Aged, 80 and over; Blood; Blood-Borne Pathogens; Child; Female; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Iran; Male; Middle Aged; Questionnaires; Risk-Taking; Seroepidemiologic Studies; Young Adult, Hepatitis B virus
Subjects: WA Public Health > WA 108-245 Preventive Medicine
WC Communicable Diseases > WC 500-590 Virus Diseases
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5397

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