Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Transcatheter closure of atrial septal defect with amplatzer device in children and adolescents: Short and midterm results; an Iranian experience

(2011) Transcatheter closure of atrial septal defect with amplatzer device in children and adolescents: Short and midterm results; an Iranian experience. Iranian Journal of Pediatrics.


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Objective: Transcatheter closure of secundum atrial septal defect (ASD) with Amplatzer device is an alternative procedure to surgical repair, with some limitations. The aim of this study was to assess the initial and mid-term results of the treatment of ASD with Amplatzer septal occluder in children and adolescents. Methods: From May 2003 to January 2008 sixty three consecutive children and adolescent patients underwent transcatheter closure of ASD at a mean±SD age of 8.5±4.8 years (range 2.2 to 18 years). All procedures were performed under local anesthesia and moderate sedation or general anesthesia with transthoracic echocardiography and fluoroscopic guidance. Stretch diameter of ASD was determined by balloon sizing catheter. Device selection was based on and matched to the standard diameter of the septal defect. Follow up at 24 hours, 1 month, 6 months, 12 months and yearly thereafter included physical examination, electrocardiography and transthoracic echocardiography. Findings: The mean ASD diameter, measured with transthoracic echocardiography and balloon catheter were 19.5± 5.5 mm and 20.9± 6.2 mm, respectively. The mean follow up period was 32.4±18.8 months. Deployment of the device was successful in 57 (90.5) and failed in 6 (9.5) patients. The major complication included dislodgement of device in 1 patient and device embolization to right ventricular inlet (surgically removed) in 1 patient. The minor complication included transient atrial tachycardia in 10 patients, paroxysmal supraventricular tachycardia in 2 patients during procedure, successfully terminated with medication. At 24 hour, 1 month, 6 month and 1 year follow up, total occlusion rates were 73.6, 91, 94.7, and 94.7, respectively. Conclusion: Transcatheter occlusion of ASD with Amplatzer device is an effective and safe procedure with minimal complication rate and short hospital stay, as well as excellent short and intermediate outcome in children and adolescents. © 2011 by Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, All rights reserved.

Item Type: Article
Additional Information: cited By 7
Keywords: age distribution; anesthesia induction; article; balloon catheter; child; clinical effectiveness; device therapy; electrocardiography; endoprosthesis loosening; female; fluoroscopy; follow up; general anesthesia; heart atrium septum defect; heart catheterization; human; Iran; local anesthesia; major clinical study; male; paroxysmal supraventricular tachycardia; patient safety; postoperative care; school child; sedation; septal occluder; supraventricular tachycardia; thromboembolism; transthoracic echocardiography; treatment failure; treatment outcome
Subjects: Cardiovascular System > WG 200-460 Heart. Heart Diseases
WS Pediatrics > WS 200-342 Diseases of Children and Adolescents
WS Pediatrics > WS 405-460 By Age Groups
Depositing User: مهندس هدی فهیم پور

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