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Hormozgan University of Medical Sciences

Association of GNB3C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension

(2011) Association of GNB3C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension. Genetics and Molecular Biology.

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Abstract

The role of G-protein activation in cardiovascular disorders is well-known. G-protein beta-3 subunit (GNB3) C825T polymorphism is associated with increased intracellular signal transduction. We investigated the role of the variant in plasma sodium and potassium concentrations and association with hypertension. 345 healthy controls and 455 patients with essential hypertension were enrolled. Plasma renin activity and aldosterone concentration were measured. The variant, typed by SNaPshot, was analyzed on an ABI Prism 3100 Genetic Analyzer and GeneScan. The TT genotype and T allele were over-represented in the patients (p < 0.001, p < 0.0001). Multiple-logistic regression disclosed that the risk of hypertension was significantly greater for TT (p < 0.0001, OR = 6.1, CI = 2.9-12.7). One-way ANOVA revealed that hypertensive T-allele carriers (CT+TT), compared to non-carriers (CC), had a greater body mass index (BMI), mean arterial pressure (MAP) and PAC(p = 0.01, p = 0.01, p< 0.0001, respectively); while the patients with 825TT risk genotype showed higher plasma sodium and lower potassium (p < 0.0001, each). The results strongly emphasize, not only the role of C825T polymorphism by the induction of increased G-protein activity and enhancement of Na/h exchangers, but also the association with higher plasma sodium and lower potassium levels, high BMI and susceptibility to hypertension. © 2011, Sociedade Brasileira de Genética.

Item Type: Article
Additional Information: cited By 8
Keywords: aldosterone; cysteine; potassium; renin; sodium; threonine, adult; allele; article; body mass; controlled study; electrolyte balance; female; G protein beta3 subunit gene; gene frequency; genetic association; genetic polymorphism; genetic susceptibility; genetic variability; genotype; human; hypertension; major clinical study; male; mean arterial pressure; mutator gene; plasma renin activity; potassium blood level; sodium blood level
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5343

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