Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Cardiovascular responses of the anterior claustrum, its mechanism; contribution of medial prefrontal cortex

(2013) Cardiovascular responses of the anterior claustrum, its mechanism; contribution of medial prefrontal cortex. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL.

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Official URL: http://www.autonomicneuroscience.com/article/S1566...

Abstract

The anterior claustrum (CLa) has bilateral connections with the areas involved in cardiovascular regulation, though its role in cardiovascular control is not yet understood. This study was performed to find the cardiovascular responsive region of the CLa by stimulating all parts of the CIA with L-glutamate, and to find the possible mechanisms mediating its responses in urethane-anesthetized rats. We also investigated the possible involvement of the medial prefrontal cortex in the cardiovascular responses of the CLa. The effect of microinjection of L-glutamate (50-100 nl, 025 M) was tested throughout the Cla and only in one area at 2.7 mm rostral to bregma, 1.8-2.0 midline and 4.5-5.6 mm vertical, significant decreases in arterial pressure were elicited (-21.71 +/- 2.1 mmHg, P < 0.001, t-test) with no significant change in heart rate. Administration (i.v.) of the muscarinic receptor blocker, atropine, had no effect on the change in mean arterial pressure in response to glutamate stimulation, suggesting that the parasympathetic system was not involved in this response. However, administration (i.v.) of the nicotinic receptor blacker, hexamethonium dichloride abolished the depressor response to glutamate, suggesting that CLa stimulation decreases sympathetic outflow to the cardiovascular system. In addition, microinjection of the reversible synaptic blacker, cobalt chloride, into the medial prefrontal cortex greatly attenuated the depressor response elicited by microinjection of glut into the CLa. Thus for the first time, we found the cardiovascular responsive region of the anterior claustrum. Also we showed that its response is mediated through the medial prefrontal cortex. (C) 2013 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: Claustrum; Glutamate; Blood pressure; Medial prefrontal cortex VENTRAL TEGMENTAL AREA; CENTRAL-NERVOUS-SYSTEM; RETROGRADE AXONAL-TRANSPORT; INSULAR CORTEX; FLUORESCENT TRACERS; HEART-RATE; CLAUSTROCORTICAL CONNECTIONS; IMMUNOHISTOCHEMICAL ANALYSIS; ELECTRICAL-STIMULATION; UNANESTHETIZED RATS
Subjects: Cardiovascular System > WG 200-460 Heart. Heart Diseases
Cardiovascular System > WG 500-700 Blood Vessels. Vascular Diseases
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5329

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