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Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Resveratrol improves diabetic retinopathy possibly through oxidative stress - Nuclear factor κB - Apoptosis pathway

(2012) Resveratrol improves diabetic retinopathy possibly through oxidative stress - Nuclear factor κB - Apoptosis pathway. Pharmacological Reports.

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Abstract

Background: This study was designed to investigate the possible effectiveness of resveratrol (trans-3,5,4'-trihydroxystilbene) administration on oxidative stress, nuclear factor κB (NF-κB) activity and apoptosis rate in streptozotocin-nicotinamide-induced diabetic retinopathy. Methods: MaleWistar rats were divided into four groups: normal control, diabetic control, normal rats treated with resveratrol, and diabetic rats treated with resveratrol. Diabetes was induced by injection of streptozotocin (50 mg/kg; ip), 15 min after the prescription of nicotinamide (110 mg/kg; ip) in 12 h fasted rats. Results: Four-month oral resveratrol administration (5 mg/kg/day) significantly alleviated hyperglycemia, weight loss, enhancement of oxidative markers (lipid peroxidation index and oxidized to reduced glutathione ratio) and superoxide dismutase activity in both blood and retinas of the diabetic rats. Moreover, resveratrol administration to diabetic rats improved the elevated levels of retinas NF-κB activity and apoptosis rate. On the other hand, four months resveratrol administration prevented from disarrangement and reduction in thickness of retinal layers. Conclusion: These beneficial antidiabetic observations suggest that resveratrol may be considered as a therapeutic supplement to prevent from diabetic retinopathy. Copyright © 2012 by Institute of Pharmacology Polish Academy of Sciences.

Item Type: Article
Additional Information: cited By 35
Keywords: glutathione; hemoglobin A1c; immunoglobulin enhancer binding protein; insulin; nicotinamide; resveratrol; streptozocin; superoxide dismutase, animal cell; animal experiment; animal model; apoptosis; article; controlled study; diabetic retinopathy; drug efficacy; enzyme activity; enzyme blood level; hemoglobin blood level; hyperglycemia; insulin blood level; male; nonhuman; oxidation reduction state; oxidative stress; rat; retina; weight reduction
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
QU Biochemistry. Cell Biology and Genetics > QU55-70 Proteins. Amino Acids. Peptides
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5302

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