Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Incidence of malignancy after living kidney transplantation: A multicen-ter study from Iran

(2012) Incidence of malignancy after living kidney transplantation: A multicen-ter study from Iran. Journal of Cancer.

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Malignancy is a common complication after renal transplantation. However, limited data are available on post-transplant malignancy in living kidney transplantation. Therefore, we made a plan to evaluate the incidence and types of malignancies, association with the main risk factors and patient survival in a large population of living kidney transplantation. We conducted a large retrospective multicenter study on 12525 renal recipients, accounting for up to 59 of all kidney transplantation in Iran during 22 years follow up period. All information was collected from observation of individual notes or computerized records for transplant patients. Two hundred and sixty-six biopsy-proven malignancies were collected from 16 Transplant Centers in Iran; 26 different type of malignancy categorized in 5 groups were detected. The mean age of patients was 46.2±12.9 years, mean age at tumor diagnosis was 50.8±13.2 years and average time between transplantation and detection of malignancy was 50.0±48.4 months. Overall tumor incidence in recipients was 2. Kaposis' sarcoma was the most common type of tumor. The overall mean survival time was 117.1 months (95 CI: 104.9-129.3). In multivariate analysis, the only independent risk factor associated with mortality was type of malignancy. This study revealed the lowest malignancy incidence in living unrelated kidney transplantation. © Ivyspring International Publisher.

Item Type: Article
Additional Information: cited By 8
Keywords: antineoplastic agent, adolescent; adult; aged; article; brain cancer; cancer incidence; cancer mortality; cancer prognosis; cancer radiotherapy; cancer surgery; child; chondrosarcoma; digestive system cancer; female; follow up; graft recipient; human; human tissue; immunosuppressive treatment; Iran; Kaposi sarcoma; kidney transplantation; living donor; lung cancer; lymphoproliferative disease; male; overall survival; risk factor; school child; skin cancer; thyroid cancer; tumor diagnosis; urogenital tract cancer
Subjects: WJ Urogenital System > WJ 300-378 Kidney
Depositing User: مهندس هدی فهیم پور

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