Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Chronic resveratrol administration has beneficial effects in experimental model of type 2 diabetic rats

(2012) Chronic resveratrol administration has beneficial effects in experimental model of type 2 diabetic rats. Endocrine Regulations.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

objective. Te present study was designed to evaluate whether long-term resveratrol administration has beneficial effects on the metabolic control and oxidative stress in diabetic rats. Methods. Male Wistar rats were divided into four groups: normal control, diabetic control, normal treated with resveratrol, and diabetic treated with resveratrol. Diabetes was induced by injection of streptozotocin (50 mg/kg; i.p.), fifteen minutes after the administration of nicotinamide (110 mg/ kg; i.p.) in 12 h fasted rats. results. Four-month oral resveratrol administration (5 mg/kg/day) significantly attenuated the elevated levels of the blood glucose, glycosylated hemoglobin, total protein, albumin, urea, creatinine, and 8-isoprostane in diabetic rats. Moreover, resveratrol administration to diabetic rats improved the reduced levels of glutathione, total antioxidant capacity, and the antioxidant enzymes activities (superoxide dismutase, glutathione peroxidase, and catalase). No significant differences were observed in the activities of plasma aminotransferases (ALT and AST) and insulin levels between diabetic rats treated with resveratrol and diabetic controls. Conclusion. Te results suggest that chronic resveratrol administration is safe and effective, and may be considered as a beneficial therapeutic compound in diabetes.

Item Type: Article
Additional Information: cited By 16
Keywords: 8 isoprostane; albumin; catalase; creatinine; glucose; glutathione; glutathione peroxidase; hemoglobin A1c; resveratrol; superoxide dismutase; urea; alanine aminotransferase; antioxidant; aspartate aminotransferase; catalase; glutathione peroxidase; glutathione peroxidase 1; resveratrol; stilbene derivative; superoxide dismutase, animal experiment; animal model; antioxidant activity; article; controlled study; ELISA kit; male; metabolic regulation; non insulin dependent diabetes mellitus; nonhuman; oral glucose tolerance test; oxidative stress; rat; spectrophotometry; weight change; animal; blood; disease model; drug effect; experimental diabetes mellitus; hyperglycemia; metabolism; Wistar rat, Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Glutathione Peroxidase; Hyperglycemia; Male; Oxidative Stress; Rats; Rats, Wistar; Stilbenes; Superoxide Dismutase
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
endocrine
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5255

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