Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Immune deviation in recurrent vulvovaginal candidiasis: Correlation with Iron Deficiency Anemia

(2013) Immune deviation in recurrent vulvovaginal candidiasis: Correlation with Iron Deficiency Anemia. Iranian Journal of Immunology.

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Abstract

Background: Iron Deficiency Anemia (IDA) has been controversially linked to IL-4 production in previous studies. A predominant Th1 response leads to resistance against recurrent vulvovaginal candidiasis (RVVC), whereas a Th2 response exacerbates the disease. Objective: To investigate the possible effect of iron deficiency on the host's susceptibility to RVVC as a result of the Th1/Th2 cytokine polarization. Methods: We conducted a case-control study of 92 women in 4 groups based on strict inclusion and exclusion criteria: RVVC+IDA+ group consisted of 23 women with RVVC and IDA; RVVC+ IDA- group consisted of 23 women with RVVC without IDA; RVVC-IDA+ group consisted of 23 women without RVVC and with IDA and RVVC- IDA- group consisted of 23 healthy women. The iron parameters and key cytokines (IFN-γ, IL-10, IL- 12, IL-4) were measured in blood samples. Results: Comparison of IL-4 production between RVVC+ IDA+ (12.2 ± 1.3 pg/ml) and RVVC+ IDA- (2.4 ± 4.0 pg/ml) groups (p=0.044), between RVVC- IDA+ (14.6 ± 1.7 pg/ml) and RVVC- IDA- (1.28 ± 3.6 pg/ml) groups (p=0.006), between RVVC- IDA+ (14.6 ± 1.7 pg/ml) and RVVC+ IDA-) 2.4 ± 4.0 pg/ml) groups (p=0.009) and also between RVVC+ IDA+ and RVVC- IDA- (1.28 ± 3.6 pg/ml) groups (p=0.03) showed significant differences. We found a significant positive correlation between IL-4 and total iron binding capacity (TIBC, p=0.046) and between serum IL-10 and Hb levels (p=0.041) in the RVVC+ IDA- group. There was also a significant negative correlation between serum IL-4 and levels of serum iron (SI, p=0.041) in the RVVC- IDA- group. Conclusion: It seems that IDA determines the balance between and the intensity of Th1 and Th2 arms of the immune response and leads to a deviation toward Th2 response which could contribute to recurrence of candidiasis.

Item Type: Article
Keywords: Cytokine Iron deficiency Recurrent vulvovaginal candidiasis Th1/th2 ferritingamma interferonhemoglobininterleukin 10interleukin 12interleukin 4iron adultarticleblood samplingcase control studycontrolled studycytokine productiondisease predispositionfemaleferritin blood levelhumanimmune responseiron binding capacityiron blood leveliron deficiency anemiamajor clinical studyprotein blood levelrecurrent diseaseTh1 cellTh2 cellvagina candidiasis Adult Anemia, Iron-DeficiencyCandidiasis, VulvovaginalCase-Control StudiesCytokinesFemaleHemoglobinsHumansIronMiddle AgedRecurrenceTh1-Th2 BalanceTh2 CellsYoung Adult
Subjects: WC Communicable Diseases > WC 450-475 Mycoses
WP Gynecology and Obstetrics > WP 650-660 Therapy
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5162

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