Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Inhibitory effects of forced swim stress and corticosterone on the acquisition but not expression of morphine-induced conditioned place preference: Involvement of glucocorticoid receptor in the basolateral amygdala

(2013) Inhibitory effects of forced swim stress and corticosterone on the acquisition but not expression of morphine-induced conditioned place preference: Involvement of glucocorticoid receptor in the basolateral amygdala. Behavioural Brain Research.

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Abstract

Addiction is a common chronic psychiatric disease which represents a global problem and stress has an important role to increase drug addiction and relapse. In the present study, we investigated the effects of physical stress and exogenous corticosterone on the acquisition and expression of morphine-induced conditioned place preference (CPP). Also, we tried to find out the role of glucocorticoid receptors (GRs) of basolateral amygdala (BLA) in this regard. In the CPP paradigm, conditioning score and locomotion activity were recorded by Ethovision software. Male adult rats received forced swim stress (FSS) as a physical stress or corticosterone (10. mg/kg; ip) as a dominant stress hormone in rodents, 10. min before morphine injection (5. mg/kg; sc) during three conditioning days (acquisition) or just prior to CPP test in the post-conditioning day (expression). In FSS procedure, animals were forced to swim for 6. min in cylinder filled with water (24-27°C). To evaluate the role of glucocorticoid receptors in the BLA, different doses of mifepristone (RU38486) as a GR antagonist were injected into the BLA (0.3, 3 and 30. ng/side) during 3-day conditioning phase before FSS or injection of corticosterone in morphine-CPP paradigm. The results showed that FSS and corticosterone reduce the acquisition but not expression of morphine-induced CPP. Moreover, blockade of GRs in the BLA could diminish the inhibitory effects of FSS or corticosterone on the acquisition of morphine-induced CPP. It seems that stress exerts its effect on reward pathway via glucocorticoid receptors in the BLA. © 2013 Elsevier B.V.

Item Type: Article
Additional Information: cited By 11
Keywords: corticosterone; glucocorticoid receptor; stress hormone, animal experiment; animal model; animal tissue; article; basolateral amygdala; controlled study; drug dependence; forced swimming test; hormone release; male; nonhuman; physical stress; place preference; priority journal; protein function; rat; reward, Basolateral amygdala; Corticosterone; Glucocorticoid receptor; Morphine; Physical stress; Reward, Amygdala; Analysis of Variance; Animals; Conditioning, Operant; Corticosterone; Hormone Antagonists; Male; Mifepristone; Morphine; Motor Activity; Narcotics; Rats; Rats, Wistar; Receptors, Glucocorticoid; Stress, Psychological; Swimming
Subjects: QV Pharmacology > QV 120-140 Autonomic Agents. Nonmetallic Elements. Neuromuscular Agents
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5111

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