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Hormozgan University of Medical Sciences

Acute pain management with intravenous 0.10 mg/kg vs. 0.15 mg/kg morphine sulfate in limb traumatized patients: A randomized double-blinded placebo-controlled trial Ekstremite yaralanmasi{dotless} olan hastalarda intravenöz 0.10 mg/kg veya 0.15 mg/kg morfin sülfat ile akut aǧri{dotless} tedavisi: Randomize çift kontrollü plasebo kontrollü çali{dotless}şma

(2013) Acute pain management with intravenous 0.10 mg/kg vs. 0.15 mg/kg morphine sulfate in limb traumatized patients: A randomized double-blinded placebo-controlled trial Ekstremite yaralanmasi{dotless} olan hastalarda intravenöz 0.10 mg/kg veya 0.15 mg/kg morfin sülfat ile akut aǧri{dotless} tedavisi: Randomize çift kontrollü plasebo kontrollü çali{dotless}şma. Ulusal Travma ve Acil Cerrahi Dergisi.

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Abstract

Background: We aimed to compare pain relief and safety of two doses of morphine in adult emergency department (ED) patients with acute limb trauma pain. Methods: A total of 200 adult ED patients over 20 years of age requiring opioid analgesia were randomly allocated to two groups. Following a first dose of intravenous morphine sulfate at 0.10 mg/kg, a randomized double-blind placebo-controlled trial of intravenous morphine sulfate at 0.05 mg/kg versus the same amount of placebo was performed. Measurement of visual analogue scale pain intensity and assessment of adverse effects were performed at baseline (before morphine at 0.10 mg/kg), 30 minutes from baseline (just before study drug administration), and at 60 minutes from baseline (30 minutes after study drug). Results: No significant difference was found between groups at 30 minutes from baseline. There was significant reduction in final pain after 1 hour in the 0.15 mg/kg compared to 0.10 mg/kg group (p<0.05). In addition, there was a significant improvement in the mean score of pain in the same group (p<0.05). The percent of pain reduction in the intervention and control group relative to the basic measures was 52.70 and 35.82, respectively. Adverse effects were present in both groups; however, there was no statistically significant difference between groups. Conclusion: Using two doses of morphine instead of one is a safe and effective method for pain reduction in isolated limb trauma. We recommend performing a second injection of 0.05 mg/kg morphine 30 minutes after the initial standard dose of 0.10 mg/ kg to decrease pain in these patients. © 2013 TJTES.

Item Type: Article
Additional Information: cited By 6
Keywords: morphine sulfate; naloxone; placebo; morphine; narcotic analgesic agent, adult; analgesia; article; controlled study; double blind procedure; drug dose comparison; drug safety; female; human; hypotension; limb injury; major clinical study; male; pain; pain assessment; pulse rate; randomized controlled trial; respiration depression; tachycardia; visual analog scale; vomiting; analgesia; emergency health service; injuries; injury; intravenous drug administration; limb; pain measurement; Pain, Intractable; treatment outcome, Adult; Analgesics, Opioid; Double-Blind Method; Emergency Service, Hospital; Extremities; Female; Humans; Injections, Intravenous; Male; Morphine; Pain Management; Pain Measurement; Pain, Intractable; Treatment Outcome; Triage; Wounds and Injuries
Subjects: WO Surgery > WO 178-198 Principles of Care. Procedures
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5106

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