Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Fluticasone nasal spray as an adjunct to amoxicillin for acute sinusitis in children: A randomized controlled trial

(2013) Fluticasone nasal spray as an adjunct to amoxicillin for acute sinusitis in children: A randomized controlled trial. European Review for Medical and Pharmacological Sciences.

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Abstract

BACKGROUND: Approximately 0.5-2 of upper respiratory tract infections in adults and 6-13 of viral upper respiratory tract infections in children are complicated by acute sinusitis. This study was aimed to evaluate the coadministration effect of fluticasone nasal spray (FNS) with amoxicillin for AS in children. PATIENTS AND METHODS: One hundred children 2 to 14 years of age with acute sinusitis referred to Shahid Mohammadi Pediatric Hospital in Bandar Abbas were randomly allocated into two equal intervention and control groups to receive amoxicillin with fluticasone nasal spray one puff twice daily for 14 days and amoxicillin 80 to 100 mg/kg/ day for 14 days respectively. RESULTS: Twenty one (42) of children in intervention group were cured completely and 2 (4) children in control group had complete recovery (p < 0.001). Symptom severity score was 22.98 ± 2.95 before treatment that reduced to 13.26 ± 3.20 after treatment (p < 0.001). CONCLUSIONS: Use of fluticasone can reduce the severity of symptoms of sinusitis in children.

Item Type: Article
Additional Information: cited By 4
Keywords: amoxicillin; fluticasone; nose spray, acute sinusitis; adolescent; article; child; clinical evaluation; controlled study; disease severity; drug effect; drug efficacy; female; human; Iran; major clinical study; male; preschool child; randomized controlled trial; school child; scoring system; single blind procedure; Symptom severity score; treatment outcome, Acute Disease; Administration, Intranasal; Adolescent; Amoxicillin; Androstadienes; Anti-Bacterial Agents; Anti-Inflammatory Agents; Child; Child, Preschool; Female; Humans; Male; Single-Blind Method; Sinusitis
Subjects: WS Pediatrics > WS 200-342 Diseases of Children and Adolescents
WV Otolaryngology > WV 300-358 Nose and Paranasal Sinuses
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5082

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