Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Association between polychlorinated biphenyls in the serum and adipose tissue with type 2 diabetes mellitus: A systematic review and meta-analysis

(2016) Association between polychlorinated biphenyls in the serum and adipose tissue with type 2 diabetes mellitus: A systematic review and meta-analysis. Int J Med Res Health Sci..

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Official URL: http://www.ijmrhs.com/archive/ijmrhs-volume-5-issu...

Abstract

Abstract Prevalence of diabetes, especially type 2 diabetes is increasing. One of the environmental risk factors of this disease is persistent organic pollutants. Studies have obtained different results in the field of association of different congeners of persistent organic pollutants such as polychlorinated biphenyls with type 2 diabetes. In this review study (systematic review and meta-analysis), the authors aimed to evaluate the association of different congeners of polychlorinated biphenyls with type 2 diabetes in both prospective and cross-sectional studies. After a systematic review, 6 prospective and 9 cross-sectional studies were evaluated. Mean of odds ratio and heterogeneity for all the studies were OR=1.97; CI (1.57-2.39)and I-2=42.9%; rho(heterogeneity)=0.009, respectively. Also, mean of odds ratio for the prospective studies (OR=1.59; CI(1.29-1.95); I-2= 2.37%; rho(heterogeneity)= 0.42) was less than that of the cross-sectional studies (OR= 2.4; CI (1.71-3.36); I-2= 49.8%; rho(heterogeneity)=0.025). Increase in different congeners of PCBs in the serum and adipose tissue can significantly increase the prevalence type 2 diabetes (p value<0.001). This study supports a positive association of polychlorinated biphenyls in the serum and adipose tissue with type 2 diabetes.

Item Type: Article
Keywords: Polychlorinated biphenyls; Diabetes; systematic review; meta-analysis; serum; adipose tissue PERSISTENT ORGANIC POLLUTANTS; CAPACITOR MANUFACTURING PLANT; ENDOGENOUS HORMONES; NATIONAL-HEALTH; EXPOSURE; OBESITY; RISK; DIOXINS; POPULATION; PREVALENCE
Subjects: WA Public Health > WA 670-847 Environmental Pollution. Sanitation
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/5052

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