Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Effect of aminoguanidine on sciatic functional index, Oxidative stress, And rate of apoptosis in an experimental rat model of ischemia-reperfusion injury

(2014) Effect of aminoguanidine on sciatic functional index, Oxidative stress, And rate of apoptosis in an experimental rat model of ischemia-reperfusion injury. Canadian Journal of Physiology and Pharmacology.

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Abstract

This study was conducted to investigate the potential protective effects of aminoguanidine (AG) on sciatic functional index (SFI), oxidative stress status, and apoptosis index using a rat model of experimental sciatic nerve ischemia-reperfusion injury (I/R). Treatment groups received 150 mg AG/kg body mass, 24 h after the induction of ischemia. After reperfusion for 2, 4, 7, 14, and 28 days, we evaluated measured SFI, plasma antioxidant enzymes, total antioxidant capacity (TAC), malondialdehyde (MDA), and index of apoptosis. SFI was significantly improved on the 7th and 14th day of reperfusion in the AG-treated groups. AG treatment resulted in the significant reduction of MDA levels on the 7th and 14th day of reperfusion. TAC was only increased after 7 days of reperfusion compared with the untreated group. SOD activity was decreased in both the untreated and AG-treated groups by comparison with the control, but did not show a significant change. GPx activity decreased only after 7 days of reperfusion. The maximal rate of apoptosis occurred on the 7th day of reperfusion. Treatment with AG significantly reduced this enhancement. AG exhibits positive effects against sciatic nerve I/R injury, possibly in part because of the protective effects of AG against apoptosis and I/R-induced oxidative stress. © National Research Council of Canada. All right reserved.

Item Type: Article
Additional Information: cited By 3
Keywords: aminoguanidine; glutathione peroxidase; malonaldehyde; superoxide dismutase; aminoguanidine; antioxidant; guanidine derivative, animal experiment; animal model; apoptosis; Article; comparative study; controlled study; enzyme activity; enzyme blood level; enzyme linked immunosorbent assay; lipid peroxidation; male; named inventories, questionnaires and rating scales; nonhuman; oxidative stress; rat; reperfusion injury; sciatic functional index; sciatic nerve injury; animal; apoptosis; drug effects; oxidative stress; pathology; pathophysiology; reperfusion injury; sciatic nerve; Sprague Dawley rat, Animals; Antioxidants; Apoptosis; Guanidines; Male; Oxidative Stress; Rats, Sprague-Dawley; Reperfusion Injury; Sciatic Nerve
Subjects: QT Physiology > QT104-172 Human Physiology
QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/4986

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