Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Natural immunity against Haemophilus influenza type B in splenectomised beta-thalassaemia children

(2014) Natural immunity against Haemophilus influenza type B in splenectomised beta-thalassaemia children. Pakistan Journal of Biological Sciences.

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Abstract

Patients with beta-thalassaemia major and asplenia have an increased risk of encapsulated bacterial infections. The aim of this study was to determine the Haemophilus influenza type b (Hib) antibody concentrations in beta-thalassaemia patients with or without spleens. The Hib antibody concentrations were investigated in 850 patients with thalassaemia major, of whom 437 had undergone splenectomy. Hib antibody levels equal or greater than 1.0 µg mL-1 were classified as long-term protection, those between 0.15 and less than 1.0 µg mL-1 as short term protection and those less than 0.15 µg mL-1 as no protection. The mean Hib antibody level was lower in asplenic subjects than in non splenectomised subjects (0.39±0.5 vs. 1.08±0.55 µg mL-1, p<0.001). The protective antibody level prevalence in asplenic patients was significantly lower than that in patients with spleens (32.3 vs. 85.7, p<0.001). Protection against Hib decreased as the time interval after splenectomy increased from 57.2 at a less than 60 months interval to 10.8 at a greater than 120 months interval (p = 0.001). Nearly 30 of the 437 splenectomised subjects had long-term protection against Hib, whereas 64.4 of the 413 non splenectomised subjects had long term protection (p<0.001). Asplenic subjects had lower Hib antibody levels than non splenectomised subjects. Additionally, the antibody levels decreased as the time interval increased after splenectomy. A Hib vaccine recommendation for splenectomised thalassaemia major seems essential. © 2014 Asian Network for Scientific Information.

Item Type: Article
Additional Information: cited By 0
Keywords: bacterium antibody; biological marker; Haemophilus vaccine, adolescent; beta-Thalassemia; blood; comparative study; female; Haemophilus Infections; Haemophilus influenzae type b; human; immunization; immunology; innate immunity; male; splenectomy; time, Adolescent; Antibodies, Bacterial; beta-Thalassemia; Biological Markers; Female; Haemophilus Infections; Haemophilus influenzae type b; Haemophilus Vaccines; Humans; Immunity, Innate; Immunization; Male; Splenectomy; Time Factors
Subjects: QY Clinical Laboratory Pathology > QY 400-490 Hematologic Tests. Blood Chemical Analysis
WC Communicable Diseases > WC 500-590 Virus Diseases
WD Disorders of Systemic, Metabolic or Environmental Origin, etc. > WD 300-380 Immunologic and Collagen Diseases. Hypersensitivity
WS Pediatrics > WS 200-342 Diseases of Children and Adolescents
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/4966

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