Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Role of oxidative stress in Male infertility

(2013) Role of oxidative stress in Male infertility. International Electronic Journal of Medicine.

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Abstract

Oxidative stress is the presence of imbalance between systemic manifestations of reactive oxygen species (ROS) and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. It has been suggested that oxidative stress plays a key role in male or female infertility. Reactive oxygen species are oxygen containing molecules that are chemically reactive. Moderate increase in oxidative stress can activate cell growth which results in normal physiologic response. Conversely highly increased oxidative stress causes cell injury (i.e. DNA and protein damage, cell membrane disruption). Nitric Oxide (NO) for instance is a free radical with vasodilating effect, and is one of the important neurotransmitters which are involved in most of the physiologic and pathologic responses. Although vasodilating effect of ROS is therapeutic, but extremely increased ROS can affect structural role of proteins and thus causes varied catabolic enzyme activity, cell signaling and cell structure. Men with increased oxidative stress and DNA destruction have increased risk of infertility which can be definitely diagnosed with sperm motility. ROS and increased oxidative stress causes a decrease in sperm motility and thus increase the probability of infertility. .

Item Type: Article
Keywords: Oxidative Stress, DNA Damage, Infertility, Male
Subjects: WP Gynecology and Obstetrics > WP 565-570 Fertility. Infertility
Depositing User: مركز تحقيقات بهداشت باروري و ناباروري
URI: http://eprints.hums.ac.ir/id/eprint/4599

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