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Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

C-Reactive Protein and Preterm Labor, a Case-Control Study

(2013) C-Reactive Protein and Preterm Labor, a Case-Control Study. Life Science Journal.

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Abstract

About 75% of prenatal mortality and morbidity is related to preterm labor and infection is a leading cause of preterm labor. Fast, non invasive and simple assessments can predict intrauterine infections in women who have no symptoms. Previous studies have shown relations between serum CRP, MMP-9, IL-6 and preterm labor. However, few studies have been conducted to evaluate the relationship between these markers and preterm labor among pregnant women. The aim of this study was to evaluate the relationship between CRP levels and preterm labor. This case control study was conducted in 2012 in Shariati Hospital of Bandar Abbas. One hundred pregnant women with a gestational age below 37 weeks were enrolled in the case group and 100 pregnant women with term deliveries were enrolled in the control group. Patients with diabetes, hypertension, premature rupture of membrane, BMI above 30, and infections were excluded from the study. Blood samples were taken from all the participants to assess CRP levels. Demographic data were also collected. Data was analyzed by SPSS v. 16 using logistic regression, descriptive statistics and odd’s ration. Among 200 participants, the mean age of the participants was 25.91 ± 6.308, and 26.93 ± 5.495 for the case and control group, respectively. The mean CRP level was 19.5082 ± 20.2566 and 6.1467 ± 5.2827 for the case and control group, respectively. This difference was significant (P<0.0001). The results of this study showed that CRP levels can predict preterm labor. However, more studies are necessary to confirm this result.

Item Type: Article
Keywords: C-reactive protein; Preterm labor; Case-control study
Subjects: WP Gynecology and Obstetrics > WP 565-570 Fertility. Infertility
Divisions: Research Vice-Chancellor Department > Fertility and Infertility Research Center
Depositing User: مركز تحقيقات بهداشت باروري و ناباروري
URI: http://eprints.hums.ac.ir/id/eprint/4587

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