Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Effect of Combined Therapy with Heparin, Clindam ycin and Cefepime on the Prevention of Intra - abdominal Adhesion in Female Rat

(2014) Effect of Combined Therapy with Heparin, Clindam ycin and Cefepime on the Prevention of Intra - abdominal Adhesion in Female Rat. Bulletin of Environm ent, Pharm acology and Life Sciences.

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Abstract

Every day, many abdomino-pelvic surgeries are performed around the world. Peritoneal adhesion is one of the most common complications of such surgeries. Many drugs have been suggested to prevent adhesion. It seems that heparin, by preventing fibrin formation, and antibiotics by preventing inflammation would decrease the incidence and severity of adhesion. The aim of this study was to determine the effect of a combined therapy with heparin, clindamycin and cefepime on the prevention of intra-abdominal adhesion in a female rat. In this experimental study, 80 female rats were divided into eight groups including control group, heparin, cefepime, clindamycin, heparin plus cefepime, heparin plus clindamycin, cefepime plus clindamycin, heparin plus cefepime plus clindamycin. After shaving and disinfecting the abdominal region, abdomen opened and multiple scratches were made in the peritoneum and then the abdomen was closed. After two weeks from the surgery, a relaparotomy was performed and a sample of the peritoneum was sent to the laboratory for adhesion grading and histopathological examination. Data was analyzed using SPSS software. According to our findings, the rats of the heparin plus cefepime plus clindamycin group showed a significantly lower incidence and severity of adherence, fibrosis, inflammation and vascular proliferation after surgery in comparison to other groups. The combination of drugs, such as heparin plus cefepime plus clindamycin has an important effect in preventing abdominal adhesions.

Item Type: Article
Keywords: Keywords: Abdominal adhesion, Heparin, Antibiotics, Female Rat
Subjects: WP Gynecology and Obstetrics > WP 650-660 Therapy
Divisions: Research Vice-Chancellor Department > Fertility and Infertility Research Center
Depositing User: مركز تحقيقات بهداشت باروري و ناباروري
URI: http://eprints.hums.ac.ir/id/eprint/4549

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