Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Fibrinolytic effects of Matricaria chamomila in preventing peritoneal adhesions

(2014) Fibrinolytic effects of Matricaria chamomila in preventing peritoneal adhesions. Bulletin of Environment harmacology and Life Sciences.

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Abstract

Abstract Abdominal wall surgeries usually result in a common consequence which is peritoneal adhesion. Matrica chamomilla (MC) is a remedial herb with anti-inflammatory biologically active compounds which are effective in prevention of post-surgical adhesions. In this prospective study, 50 female rats were divided into 5 groups which received normal saline, chamomile extracts of 100mg/kg 200mg/kg 400 mg/kg and a control group. Intra-peritoneal ketamine 30 mg/kgwas administered for anesthesia. After surgical preparation of the abdomen, several scratches were made in the peritoneum and the abdominal wall was closed. Repeated laparotomy was performed 2 weeks later, and the peritoneum was biopsied for histo-pathological examination and grading of the adhesions. Data were analyzed with SPSS 13. Analysis was done using student's t-test, chi square, Kruskal-Wallis and Mann-Whitney U tests. If the value of p≤ 0.05 the results were considered significant. The results show that adhesion, fibrosis, inflammation, and post-surgical vascularization was significantly less in chamomile group compared to rats receiving normal saline or the control group (p≤0.001). Chamomile has protective anti-inflammatory effects proved by significant restraining of the post-surgical adhesions. ( Fibrinolytic effects of Matricaria chamomila in preventing peritoneal adhesions (PDF Download Available). Available from: https://www.researchgate.net/publication/268432454_Fibrinolytic_effects_of_Matricaria_chamomila_in_preventing_peritoneal_adhesions [accessed Jan 27 2018].

Item Type: Article
Keywords: Fibrinolytic Matricaria chamomila peritoneal adhesions
Subjects: WP Gynecology and Obstetrics > WP 565-570 Fertility. Infertility
Divisions: Research Vice-Chancellor Department > Fertility and Infertility Research Center
Depositing User: مركز تحقيقات بهداشت باروري و ناباروري
URI: http://eprints.hums.ac.ir/id/eprint/4548

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