Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

The imbalance in expression of angiogenic and anti-angiogenic factors as candidate predictive biomarker in preeclampsia

(2015) The imbalance in expression of angiogenic and anti-angiogenic factors as candidate predictive biomarker in preeclampsia. Iranian Journal of Reproductive Medicine.

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Abstract

Preeclampsia is an important pregnancy disorder with serious maternal and fetal complications which its etiology has not been completely understood yet. Early diagnosis and management of disease could reduce its potential side effects. The vascular endothelial growth factor (VEGF) family including VEGF-A is the most potent endothelial growth factor which induces angiogenesis and endothelial cell proliferation and has basic role in vasculogenesis. VEGF and its tyrosine kinase receptors (Flt1 and KDR) are major factors for fetal and placental angiogenic development. Finding mechanisms involved in expression of angiogenic factors may lead to new prognostic and therapeutic points in management of preeclampsia. Recent researches, has shown capability of some anti-angiogenic factors as potential candidate to be used as early predictors for preeclampsia. Soluble fms-like tyrosin kinase-1 (sFlt1) is a truncated splice variant of the membrane-bound VEGF receptor Flt1, that is produced by the placenta and it can bind to angiogenic growth factors and neutraliz, their effects. It is also observed that the ratio of sFlt1 to placental growth factor is valuable as prognostic marker. In this review, VEGF family member’s role in angiogenesis is evaluated as biomarkers to be used for prediction of preeclampsia. © 2015, Research and Clinical Center for Infertitlity. All rights reserved.

Item Type: Article
Additional Information: cited By 5
Keywords: angiogenic factor; anti angiogenic factor; biological marker; endoglin; placental growth factor; soluble fms like tyrosine kinase 1; unclassified drug; vasculotropin; vasculotropin A; vasculotropin B; vasculotropin C; vasculotropin D; vasculotropin E; vasculotropin receptor 1; vasculotropin receptor 2; angiogenic factor; biological marker; messenger RNA; transforming growth factor beta1; vasculotropin receptor 1; vasculotropin receptor 2, angiogenesis; cell proliferation; disease severity; Doppler echography; early diagnosis; enzyme activity; human; prediction; predictive value; preeclampsia; pregnancy; protein blood level; protein expression; protein synthesis; Review; sensitivity and specificity; angiogenesis; disease association; DNA microarray; Doppler flowmetry; gene expression regulation; gestational age; intrauterine growth retardation; real time polymerase chain reaction
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
WQ Obstetrics > WQ 215-270 Pregnancy Complications
Divisions: Research Vice-Chancellor Department > Fertility and Infertility Research Center
Research Vice-Chancellor Department > Molecular Medicine Research Center
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/4468

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