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Hormozgan University of Medical Sciences

Predictive accuracy of urinary β2-microglobulin for kidney injury in children with acute pyelonephritis

(2015) Predictive accuracy of urinary β2-microglobulin for kidney injury in children with acute pyelonephritis. Iranian Journal of Kidney Diseases.

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Abstract

Introduction. Leukocyte count, erythrocyte sediment rate and C-reactive protein are available laboratory markers which may be helpful in prediction of technetium Tc 99m dimercaptosuccinic acid (DMSA) renal scintigraphy results. None of these, however, have enough accuracy for prediction of renal injury and scar. This study was aimed to evaluate the diagnostic accuracy of urinary β2-microglobulin in detection of renal injury in children with acute pyelonephritis. Materials and Methods. Eighty-nine children between 2 months and 14 years old with the diagnosis of acute pyelonephritis that had no past history of infection in the urinary tract system were enrolled in the study. A standard urine sample according to patients’ age was obtained for urine culture, urinalysis, and urinary β2-microglobulin tests. Blood sample was obtained for leukocyte count, creatinine, blood urea nitrogen, C-reactive protein, erythrocyte sediment rate, and electrolytes tests. All patients underwent DMSA scan. Results. The cutoff point for urinary β2-microglubulin for prediction of positive DMSA scan was 0.8 mg with a sensitivity of 40.9 (95 CI, 26.3 to 56.8) and a specificity of 84.1 (95 CI, 69.9 to 93.4), a positive predictive value of 72.0 (95 CI, 50.6 to 87.9) and an negative predictive value of 58.7 (95 CI, 45.6 to 71.0). Conclusions. Urinary β2-microglobulin is not enough sensitive and specific to be used as a diagnostic marker for prediction of renal injury. Other common markers such as erythrocyte sediment rate, leukocyte count, and C-reactive protein can be used in combination to predict kidney injury in children with acute pyelonephritis. © 2015, Iranian Society of Nephrology. All rights reserved.

Item Type: Article
Additional Information: cited By 3
Keywords: beta 2 microglobulin; C reactive protein; creatinine; succimer; beta 2 microglobulin; biological marker; C reactive protein; creatinine, acute pyelonephritis; adolescent; Article; child; controlled study; cross-sectional study; diagnostic accuracy; diagnostic test accuracy study; electrolyte blood level; erythrocyte sedimentation rate; female; human; infant; kidney injury; kidney scintiscanning; leukocyte count; major clinical study; male; predictive value; sensitivity and specificity; urea nitrogen blood level; urinalysis; acute disease; area under the curve; blood; evaluation study; preschool child; pyelonephritis; receiver operating characteristic; reproducibility; urine, Acute Disease; Adolescent; Area Under Curve; beta 2-Microglobulin; Biological Markers; Blood Sedimentation; Blood Urea Nitrogen; C-Reactive Protein; Child; Child, Preschool; Creatinine; Cross-Sectional Studies; Female; Humans; Infant; Leukocyte Count; Male; Predictive Value of Tests; Pyelonephritis; Reproducibility of Results; ROC Curve; Urinalysis
Subjects: WJ Urogenital System > WJ 400-600 Ureter. Bladder. Urethra
WS Pediatrics > WS 200-342 Diseases of Children and Adolescents
WS Pediatrics > WS 405-460 By Age Groups
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Departments of Clinical Sciences > Department of Pediatrics
Education Vice-Chancellor Department > Faculty of Medicine > Departments of Clinical Sciences > Department of Urology
Research Vice-Chancellor Department > Infectious and Tropical Diseases Research Center
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/4461

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