Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Swim training improves HOMA-IR in type 2 diabetes induced by high fat diet and low dose of streptozotocin in male rats

(2015) Swim training improves HOMA-IR in type 2 diabetes induced by high fat diet and low dose of streptozotocin in male rats. Advanced Pharmaceutical Bulletin.

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Abstract

Purpose: Insulin resistance plays a key role in the onset and development of type 2 diabetes mellitus (T2DM) and its complications. In this study, we evaluated the effect of swim training on insulin resistance in diabetic rats. Methods: Forty male Wistar rats were randomly divided into four groups (n=10): sedentary control (Con), sedentary diabetic (Dia), swim trained control (Exe) and swim trained diabetic (Dia+Exe) rats. Diabetes was induced by high fat diet (HFD) and a low dose of streptozotocin (35 mg/kg, i.p). In trained groups, one week after the induction of diabetes, animals were subjected to swimming (60 min/5 days a week) for 10 weeks. At the end of training, fasting blood sugar (FBS), oral glucose tolerance test (OGTT), fasting/basal insulin, glycosylated hemoglobin (HbA1c) levels, insulin resistance index, homeostasis model assessment method (HOMA-IR), triglycerides (TG,) total cholesterol (TCh), and high density lipoprotein (HDL) levels in blood were measured. Results: Swimming significantly improved OGTT (P<0.01) and HOMA-IR (P<0.01). Swim training also significantly decreased FBS (p<0.01), fasting/basal insulin (P<0.01), HbA1C (p<0.01), TG (P<0.05), and TCh (P<0.05) levels. It also significantly increased HDL (p<0.05) level. Conclusion: Our findings indicate that swim training improved glycemic control andinsulin sensitivity in type 2 diabetes caused by high fat diet in male rats. © 2015 The Authors.

Item Type: Article
Additional Information: cited By 3
Keywords: cholesterol; glucose; hemoglobin A1c; high density lipoprotein; insulin; triacylglycerol, animal experiment; animal model; Article; cholesterol blood level; clinical effectiveness; controlled study; glucose blood level; glycemic control; hemoglobin blood level; homeostasis model assessment insulin resistance; insulin blood level; insulin resistance; insulin sensitivity; lipid diet; lipoprotein blood level; male; metabolic parameters; non insulin dependent diabetes mellitus; nonhuman; oral glucose tolerance test; outcome assessment; rat; sedentary lifestyle; streptozotocin-induced diabetes mellitus; swimming; training; triacylglycerol blood level
Subjects: WA Public Health > WA 108-245 Preventive Medicine
WD Disorders of Systemic, Metabolic or Environmental Origin, etc. > WD 100-175 Nutrition Disorders
endocrine
Divisions: Research Vice-Chancellor Department > Molecular Medicine Research Center
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/4443

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