Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Considering the prominent complaint as a guide in medical therapy for overactive bladder syndrome in women over 45 years

(2015) Considering the prominent complaint as a guide in medical therapy for overactive bladder syndrome in women over 45 years. Journal of Obstetrics and Gynaecology Research.

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Aim The aim of this study was to evaluate the response of women over 45 years with overactive bladder and detrusor overactivity to a 12-week course of oxybutynin or tolterodine treatment. Material and Methods A total of 301 eligible Iranian women were studied. In this double-blinded trial, data were analyzed from 3-day urinary diaries from before and after 12 weeks of treatment in which patients were randomly assigned to receive oxybutynin or tolterodine in recommended doses. Patients' convenience and the drugs' side-effects were assessed by a monthly clinical appointment. End-points were changed from baseline to week 12 in bladder-diary variables and all observed or reported adverse events. The effectiveness of each drug was studied using the paired t-test and improvement after treatment between the two groups was compared by independent t-test. Results Mean improvements in the terms of urgency (P = 0.64) and urge incontinence (P = 0.75) showed an insignificantly larger score in patients who were treated by oxybutynin. Improvement in night-time urinary urgency and nocturia (41.2 and 54.3 vs 39.7 and 40.1 in oxybutynin vs tolterodine groups, respectively) were shown to be more improved by tolterodine in comparison to oxybutynin (P = 0.72 and 0.04 for night-time urinary urgency and nocturia, respectively). Discontinuation of treatment due to adverse events was not significantly different in the two groups. Conclusions Oxybutynin and tolterodine showed similar efficacy on daytime symptoms of overactive bladder and similar side-effects in perimenopausal patients. For patients with the chief complaint of nocturnal frequency, prescription of tolterodine is preferably suggested. © 2014 The Authors.

Item Type: Article
Additional Information: cited By 0
Keywords: oxybutynin; tolterodine; mandelic acid derivative; muscarinic receptor blocking agent; oxybutynin; tolterodine, abdominal cramp; adult; Article; blurred vision; constipation; controlled study; double blind procedure; drug efficacy; drug withdrawal; female; human; major clinical study; nausea; nocturia; nocturnal enuresis; overactive bladder; randomized controlled trial; urge incontinence; urinary urgency; urine retention; xerostomia; aged; comparative study; middle aged; Urinary Bladder, Overactive, Aged; Double-Blind Method; Female; Humans; Mandelic Acids; Middle Aged; Muscarinic Antagonists; Tolterodine Tartrate; Urinary Bladder, Overactive
Subjects: WJ Urogenital System > WJ 400-600 Ureter. Bladder. Urethra
Depositing User: مهندس هدی فهیم پور

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