Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

A review of malignant bone tumors

(2015) A review of malignant bone tumors. Research Journal of Pharmaceutical, Biological and Chemical Sciences.


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Bone tumors can either be benign (non-cancerous) or malignant (cancerous). The latter are more prevalent than the former. The two types of tumor manage to grow and put a pressure on a healthy bone tissue, get absorbed in it, and finally replace the healthy tissue by an unnatural one. Benign tumors which are not spread are seldom life-threatening. A cancer which stems from bones (primary bone cancer) does not resemble a cancer spread throughout bones from other parts of body (secondary bone cancer). Primary bone cancer is scarce. In America, about 2,500 new cases of bone cancer are diagnosed annually. Prevalently, bone cancers occur as a result of the spreading of metastatic cancers in other body organs such as breasts, lungs and prostate. The most prevalent type of bone cancer is called osteosarcoma which appears in new bone tissues which are growing. Another type of bone cancer is chondrosarcoma which arises from cartilage. Ewing's sarcoma is yet another type of bone cancer which is estimated to stem from immature neural tissues in bone marrow. Osteosarcoma and Ewing's sarcomaare often prevalent among children and adolescents, while chondrosarcoma is mostly evident in adults. Bone osteosarcoma involves knees, upper parts of arms; chondrosarcoma involves pelvic cartilage and the upper parts of ankles and shoulders; Ewing's sarcoma in turn involves immature neural tissues often in pelvic bone marrow, upper parts of ankles, ribs and arms. Pain is the most common symptom of bone cancer. Symptoms are dependent on the cancerous organ and also the size of cancer. Tumors appearing in joints or near them cause inflammation or sensitivity in the afflicted area. Moreover, bone cancer disrupts the natural movement of bones and also weakens them. Occasionally, it causes fracture in them. Among its other symptoms are fatigue, fever, loss of weight and anemia. None of these symptoms, though, are definite signs of cancer. They might occur as a result of other non-threatening circumstances. However, they need to be controlled by physicians. Different tests are used to precisely diagnose this disease and examine the form and spread of cancer. These include blood or urine tests and medical imaging methods such as simple radiography, sonography, CT scan, MRI or radionuclide scan (bone scan). In the majority of cases, diagnosing the type of bone tumor depends on extracting part of the afflicted tissue and examine it microscopically. Several methods are used to treat bone tumors. It needs to be mentioned that to treat some of these tumors especially the malignant, more than one method is used simultaneously or consecutively. The key therapeutic methods for bone tumors are radiotherapy, chemotherapy and surgery.

Item Type: Article
Additional Information: cited By 0
Keywords: dexamethasone; doxorubicin; methylprednisolone; prednisolone; thalidomide; vincristine, allogeneic stem cell transplantation; blood analysis; bone marrow transplantation; bone radiography; bone scintiscanning; breast cancer; cancer chemotherapy; cancer classification; cancer diagnosis; cancer localization; cancer pain; cancer radiotherapy; cancer recurrence; cancer surgery; chondrosarcoma; clinical feature; computer assisted tomography; echography; Ewing sarcoma; human; lung cancer; monoclonal immunoglobulinemia; multiple myeloma; nuclear magnetic resonance imaging; osteosarcoma; pancytopenia; prevalence; prostate cancer; Review; risk factor; symptomatology; tumor volume; urinalysis
Subjects: QZ Pathology > QZ 200-380 Neoplasms
Divisions: Research Vice-Chancellor Department > Student Research Committee
Depositing User: مهندس هدی فهیم پور

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