Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Cardiovascular baroreflex sensitivity attenuates by cisplatin-induced toxicity in rats

(2015) Cardiovascular baroreflex sensitivity attenuates by cisplatin-induced toxicity in rats. Physiology and Pharmacology.

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Abstract

Introduction: Cisplatin (CP) therapy may disturb cardiovascular system control. The objective of this study was to find baroreflex sensitivity (BRS) in CP-induced nephrotoxicity in rats. Materials and Methods: Eighteen male and female Wistar rats were randomly assigned to two groups; treated with CP (2.5 mg/kg/day) and the vehicle, for five consecutive days, and then were subjected to surgical procedure to determine BRS using three different doses (0.025, 0.05 and 0.1 mg/kg) of α-adrenergic receptor agonist phenylephrine (PE). Results: Serum levels of blood urea nitrogen and creatinine, kidney weight, and kidney tissue damage score were increased in CP-treated animals. All doses of PE injection caused MAP increase and HR decrease. However, ΔMAP and ΔHR response to 0.1 mg/kg of PE were significantly lower in the CP-treated group (P<0.05). BRS also was increased in a dosedependent manner by PE in vehicle-treated group, but this was not the case in the CP-treated animals, and significant difference in BRS was detected between the two groups (P<0.05) when 0.05 or 0.1 mg/kg of PE were infused. Conclusion: CP-induced nephrotoxicity attenuates BRS possibly due to peripheral effect on the vascular system. © 2015, Iranian Society of Physiology and Pharmacology. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Keywords: cisplatin; creatinine; phenylephrine, animal experiment; animal tissue; Article; cardiovascular baroreflex sensitivity; carotid artery flow; controlled study; female; heart rate; histopathology; kidney mass; kidney tissue damage score; male; mean arterial pressure; nephrotoxicity; nonhuman; pressoreceptor reflex; rat; scoring system; urea nitrogen blood level
Subjects: Cardiovascular System > WG 200-460 Heart. Heart Diseases
Cardiovascular System > WG 500-700 Blood Vessels. Vascular Diseases
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Physiology Medical
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/4363

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