Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Association study of interleukin-1 family and interleukin-6 gene single nucleotide polymorphisms in recurrent aphthous stomatitis

(2015) Association study of interleukin-1 family and interleukin-6 gene single nucleotide polymorphisms in recurrent aphthous stomatitis. International Journal of Immunogenetics.

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Recurrent aphthous stomatitis (RAS) is a common painful, ulcerative oral inflammatory disorder with unknown aetiology. Immune system and aberrant cytokine cascade deemed to be critical in outbreaks of RAS ulcers. Interleukin-1 (IL-1) and IL-6 are the most potent pro-inflammatory cytokines. Single nucleotide polymorphisms (SNPs) of IL-1 and IL-6 genes can affect the secretion of these cytokines. The aim of this study was to investigate the association between RAS and IL-6 and IL-1 in Iranian subjects with minor RAS. Genomic DNA was obtained from 64 Iranian patients with RAS. IL-1α C -889 T, IL-1β C -511 T, IL-1β C +3962 T, IL-1R C pst-I 1970 T, IL-1Ra C Mspa-I11100 T, IL-6 C -174 G and IL-6 A nt +565 G polymorphisms were determined using polymerase chain reaction with sequence-specific primers (PCR-SSP). The frequency of C -174 C genotype in the patients group was significantly different from the healthy control. No other significant differences were found in genotype and alleles frequencies between the two groups. These results indicate that certain SNPs of IL-6 gene at position -174 which located in promoter have association with predisposition of individuals to RAS. © 2015 John Wiley & Sons Ltd.

Item Type: Article
Additional Information: cited By 8
Keywords: genomic DNA; interleukin 1; interleukin 1 receptor; interleukin 1 receptor alpha; interleukin 1alpha; interleukin 1beta; interleukin 6; interleukin receptor; unclassified drug; interleukin 1; interleukin 6, adult; allele; aphthous stomatitis; Article; controlled study; female; gene frequency; genotype; human; Iranian (citizen); major clinical study; male; polymerase chain reaction; priority journal; promoter region; single nucleotide polymorphism; aphthous stomatitis; case control study; genetic association study; genetic predisposition; genetics; Iran; middle aged; young adult, Adult; Alleles; Case-Control Studies; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-1; Interleukin-6; Iran; Male; Middle Aged; Polymorphism, Single Nucleotide; Stomatitis, Aphthous; Young Adult
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Divisions: Research Vice-Chancellor Department > Molecular Medicine Research Center
Depositing User: مهندس هدی فهیم پور

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