Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Effect of ursodeoxycholic acid on indirect hyperbilirubinemia in neonates treated with phototherapy

(2016) Effect of ursodeoxycholic acid on indirect hyperbilirubinemia in neonates treated with phototherapy. Journal of Pediatric Gastroenterology and Nutrition.

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Background: Hyperbilirubinemia is a common neonatal problem. The present study aimed to investigate the effect of ursodeoxycholic acid in reducing indirect hyperbilirubinemia of infants under phototherapy. Methods: This double-blind randomized clinical trial was conducted on neonates with jaundice, who had received phototherapy in the hospitals affiliated with the Shiraz University of Medical Sciences in 2013. A total of 80 neonates were enrolled in the study and were randomly divided into 2 groups. The intervention group (n =40) with indirect hyperbilirubinemia received 10 mg ·kg-1 · day-1 divided every 12 hours Ursobil (capsule 300 mg) in addition to phototherapy, whereas the control group (n =40) received only phototherapy. Total bilirubin levels were measured every 12 hours until reaching <10 mg/dL, and then phototherapy was disrupted. The duration of phototherapy was measured. The 2 groups were compared regarding total bilirubin levels at different time points and duration of phototherapy using the generalized estimating equation (GEE) test. Results: The mean of total bilirubin in the intervention group was 12±1.6, 10±1.1, and 9.8±0.2 mg/dL 12, 24, and 48 hours after the beginning of phototherapy, respectively. On the contrary, these measures were 14.4±1.3, 12.5±1.4, and 10.1±1.1 mg/dL in the control group, respectively, (P<0.05). The mean time required for phototherapy to decrease the bilirubin level to <10 mg/dL was 15.5±6 and 44.6±13.3 hours in the case and the control group, respectively, (P =0.001). Conclusions: Ursodeoxycholic acid had additive effect with phototherapy in neonates with indirect hyperbilirubinemia. This drug also reduced the time period needed for phototherapy and, consequently, decreased the hospitalization period. © 2015 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

Item Type: Article
Additional Information: cited By 0
Keywords: bilirubin; placebo; ursodeoxycholic acid; bilirubin; cholagogue; ursodeoxycholic acid, Article; bilirubin blood level; controlled study; double blind procedure; drug effect; female; human; hyperbilirubinemia; major clinical study; male; newborn; phototherapy; priority journal; randomized controlled trial; treatment duration; treatment outcome; blood; complication; hyperbilirubinemia; jaundice; length of stay; multimodality cancer therapy; phototherapy; procedures; time factor, Bilirubin; Cholagogues and Choleretics; Combined Modality Therapy; Double-Blind Method; Female; Humans; Hyperbilirubinemia; Infant, Newborn; Jaundice; Length of Stay; Male; Phototherapy; Time Factors; Treatment Outcome; Ursodeoxycholic Acid
Subjects: WS Pediatrics > WS 360-368 Pediatric Specialties
Depositing User: هدی فهیم پور

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