Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

FoxP3 gene promoter polymorphism affects susceptibility to preeclampsia

(2016) FoxP3 gene promoter polymorphism affects susceptibility to preeclampsia. Human Immunology.

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Abstract

Background Preeclampsia (PE) is a multifactorial pregnancy disorder and is a major cause of maternal morbidity and mortality. Despite intense study, the pathophysiology of preeclampsia remains enigmatic. Recent studies have reported that regulatory T cells (Tregs) is linked with PE. It is well identified that FoxP3/Scurfin is involved in development and function of Tregs. However, the association between PE and the FoxP3 gene polymorphism has not been sufficiently investigated. In this study, we hypothesized that polymorphisms of the FoxP3 may be related to PE. Methods We assessed the relationship between four single-nucleotide polymorphisms (SNPs) in the FoxP3 genes with sequence-specific primers (PCR-SSP) in 81 PE patients and 90 age-matched controls. Result We identified significant difference of rs4824747 GG genotype frequency between the PE and control groups. Women with GG genotypes exhibited higher (OR = 6.25, 95 CI = 2.63–14.85; P < 0.0001) risk of developing PE. None of the other investigated SNPs (rs2232365, rs3761547 and rs3761548) showed significant association with PE. Conclusion We suggest that FoxP3 polymorphisms (rs4824747) could be a potential contributor for the development of PE in Iranian women. © 2016 American Society for Histocompatibility and Immunogenetics

Item Type: Article
Additional Information: cited By 1
Keywords: transcription factor FOXP3; forkhead transcription factor; FOXP3 protein, human, adult; Article; body mass; controlled study; disease predisposition; female; gene frequency; genetic risk; genotype; gestational age; human; Iranian people; major clinical study; maternal age; nullipara; obstetric delivery; preeclampsia; pregnant woman; priority journal; promoter region; regulatory T lymphocyte; single nucleotide polymorphism; case control study; genetic association study; genetic predisposition; genetics; Iran; preeclampsia; pregnancy; risk; single nucleotide polymorphism; young adult, Adult; Case-Control Studies; Female; Forkhead Transcription Factors; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Iran; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Risk; Young Adult
Subjects: WQ Obstetrics > WQ 215-270 Pregnancy Complications
Divisions: Education Vice-Chancellor Department > Faculty of Nursing and Midwifery > Department of Midwifery
Research Vice-Chancellor Department > Mother and Child Welfare Research Center
Depositing User: هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/4241

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