Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Digit-length ratios (2D:4D) as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia: A descriptive-analytic study of 1200 Iranian men

(2016) Digit-length ratios (2D:4D) as a phenotypic indicator of in utero androgen exposure is not prognostic for androgenic alopecia: A descriptive-analytic study of 1200 Iranian men. Dermatology Reports.

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Abstract

The etiology of androgenic alopecia (AGA) involves several factors, including genetics, androgens, age and nutrition. Digit-length ratio of the index and ring finger (2D:4D) is an indicator of prenatal exposure to sex hormones. There is a paucity of studies that systemically review the possible positive predictive value of 2D:4D in the development of AGA. We performed a single-site, descriptive-analytical study among a racially homogeneous population. Our results revealed that no significant association was determined between right 2D:4D and AGA severity within our entire population (P=0.384, r=0.025), however a positive correlation coefficient was identified in subjects above the age of 40. Based on the receiver operating characteristic curve analysis, 2D:4D does not predict the development of AGA. AGA is truly a multifactorial disease. Further, our findings suggest that increased in utero exposure to androgens as a fetus does not predispose men to develop AGA. © Amir Feily et al., 2016.

Item Type: Article
Additional Information: cited By 1
Keywords: androgen, adult; age; Article; descriptive research; digit length ratio; disease severity; finger; hair loss; human; Iranian people; male; male type alopecia; predictive value; prenatal exposure; receiver operating characteristic
Subjects: WR Dermatology > WR 140-340 Skin Diseases
Depositing User: هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/4192

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