Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Regulatory T-cells and preeclampsia: An overview of literature

(2016) Regulatory T-cells and preeclampsia: An overview of literature. Expert Review of Clinical Immunology.

[img] Archive
1744666X.2016.1105740 - Other

Download (827B)

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Regulatory T-cells (Tregs) are key players in successful pregnancy and their deficiencies are implicated in pregnancy complications such as preeclampsia (PE), but the results are inconsistent among studies. This study aims to compile an overview of the studies about the associations of Tregs and PE risk and to provide recommendations for future research. A sensitive search of three databases including PubMed, Scopus and Google scholar (from 1995 to January 9, 2015) identified 636 unique titles. An accurate process of study selection, data extraction and method qualification were independently conducted by authors on retrieved papers. Seventeen papers met the inclusion criteria and were included in quality assessment. Regarding the source of Tregs, 14 studies assessed Tregs in peripheral blood, 2 studies in peripheral blood and decidua and one study in peripheral blood and umbilical cord blood. Despite variation in the combinations of markers and other aspects of the studies designs, remarkable constancy in the results of studies that measured Tregs as CD4+FoxP3+ or CD4+CD25+FoxP3+ cells (but not CD4+CD25high/lowFoxP3+ markers) was found, which in broad terms showed a shift towards fewer Treg cells in PE. This review revealed an association between lower percentage of circulating CD4+FoxP3+ or CD4+CD25+FoxP3+ Tregs and the risk of PE. Given the above issue and regarding the high consistency of studies on reduction of suppressive activity of Tregs in PE, we have proposed a model in which the Tregs deficiency is a reflection of immune endocrine imbalance, which reverses maternal tolerance and results in development of preeclampsia. © 2015 Taylor & Francis.

Item Type: Article
Additional Information: cited By 11
Keywords: corticosteroid; forkhead transcription factor; FOXP3 protein, human; interleukin 2 receptor alpha, CD4+ CD25+ T lymphocyte; cell count; disease severity; gestational age; human; Medline; preeclampsia; regulatory T lymphocyte; Review; Scopus; systematic review; female; immunological tolerance; immunology; lymphocyte count; metabolism; preeclampsia; pregnancy; regulatory T lymphocyte, Female; Forkhead Transcription Factors; Humans; Immune Tolerance; Interleukin-2 Receptor alpha Subunit; Lymphocyte Count; Pre-Eclampsia; Pregnancy; T-Lymphocytes, Regulatory
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 100-133 Biochemistry of the Human Body
QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Biochemistry
Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Immunology Department
Research Vice-Chancellor Department > Molecular Medicine Research Center
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/4092

Actions (login required)

View Item View Item