Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Brain derived neurotrophic factor modification of epileptiform burst discharges in a temporal lobe epilepsy model

(2016) Brain derived neurotrophic factor modification of epileptiform burst discharges in a temporal lobe epilepsy model. Basic and Clinical Neuroscience.

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Abstract

Introduction: Transforming Growth Factor-Beta 1 (TGF-β1) is a pleiotropic cytokine with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of Ischemic Stroke (IS), by involving in the pathophysiological progression of hypertension, atherosclerosis, and lipid metabolisms. -509C/T TGF-β1 gene polymorphism has been found to be associated with the risk of IS. The aim of this meta-analysis was to provide a relatively comprehensive account of the relation between -509C/T gene polymorphisms of TGF-β1 and susceptibility to IS. Methods: Male Wistar rats were divided into sham (receiving phosphate buffered saline within dorsal hippocampus), pilocarpine (epileptic model of TLE), single injection BDNF (epileptic rats which received single high dose of BDBF within dorsal hippocampus), and multiple injections BDNF (epileptic rats which received BDNF in days 10, 11, 12, and 13 after induction of TLE) groups. Their electrocorticogram was recorded and amplitude, frequency, and duration of spikes were evaluated. Results: Amplitude and frequency of epileptiform burst discharges were significantly decreased in animals treated with BDNF compared to pilocarpine group. Conclusion: Our findings suggested that BDNF may modulate the epileptic activity in the animal model of TLE. In addition, it may have therapeutic effect for epilepsy. More studies are necessary to clarify the exact mechanisms of BDNF effects.

Item Type: Article
Additional Information: cited By 3
Keywords: brain derived neurotrophic factor; pilocarpine, animal cell; animal experiment; animal model; animal tissue; anticonvulsant activity; Article; brain ischemia; controlled study; disease predisposition; DNA polymorphism; dorsal hippocampus; dose response; drug megadose; electrocorticography; epileptic discharge; epileptic state; genetic susceptibility; male; neuromodulation; nonhuman; rat; risk factor; single drug dose; spike wave; temporal lobe epilepsy; TGF beta1 gene; treatment outcome
Subjects: WL Nervous System > WL 102.5-102.9 Neurons
WL Nervous System > WL 200-405 Central Nervous System. Disorders. Therapeutics
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Education
Depositing User: هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/4088

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