Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Vaginal misoprostol versus intravenous oxytocin for the management of second-trimester pregnancies with intrauterine fetal death: A randomized clinical trial

(2016) Vaginal misoprostol versus intravenous oxytocin for the management of second-trimester pregnancies with intrauterine fetal death: A randomized clinical trial. Journal of Obstetrics and Gynaecology Research.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Aim The aim of this study was to compare vaginal misoprostol versus intravenous (i.v.) oxytocin in the management of pregnancies with second-trimester intrauterine fetal death (IUFD). Methods This randomized clinical trial was conducted on 85 pregnant women with IUFD and unripe cervix who were admitted for labor induction. Forty were randomly allocated to receive 200 mcg vaginal misoprostol every 12 h, and 45 were randomly assigned to receive high-dose i.v. oxytocin (starting from 6 mU/min to reach the maximum dose of 40 mU/min). This study is registered at www.irct.ir (IRCT201307159568N5). Results The induction-to-delivery interval in the misoprostol group (10.5 ± 5.3 range 4-27 h) was significantly lower than that in the oxytocin group (14 ± 6.8 range 4-30 h) (P = 0.009). The total hospital stay in the misoprostol group (22.6 ± 9.5 range 12-48 h) was significantly lower than that in the oxytocin group (35.3 ± 16.4 range 12-72 h) (P = 0.000). Although the successful induction rate was higher in the misoprostol group, this was not significant (95% vs 86.7%, P = 0.1). Placenta retention occurred more in the oxytocin group (20% vs 5%, P = 0.03). Conclusion Both vaginal misoprostol and high-dose i.v. oxytocin are highly effective in labor induction in second-trimester pregnancies with IUFD and an unripe cervix. However, vaginal misoprostol seems to be superior to i.v. oxytocin. © 2015 Japan Society of Obstetrics and Gynecology.

Item Type: Article
Additional Information: cited By 1
Keywords: misoprostol; oxytocin; abortive agent; misoprostol; oxytocic agent; oxytocin, adult; Article; controlled study; drug dose increase; drug megadose; female; fetus death; gestational age; human; intermethod comparison; labor induction; length of stay; major clinical study; postpartum hemorrhage; randomized controlled trial; retained placenta; second trimester pregnancy; uterine cervix; fetus death; induced abortion; intravaginal drug administration; intravenous drug administration; outcome assessment; pregnancy; procedures; second trimester pregnancy; young adult, Abortifacient Agents, Nonsteroidal; Abortion, Induced; Administration, Intravaginal; Adult; Female; Fetal Death; Humans; Infusions, Intravenous; Misoprostol; Outcome Assessment (Health Care); Oxytocics; Oxytocin; Pregnancy; Pregnancy Trimester, Second; Young Adult
Subjects: WQ Obstetrics > WQ 200-212 Reproduction. Pregnancy
WS Pediatrics > WS 360-368 Pediatric Specialties
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Departments of Clinical Sciences > Department of Pediatrics
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/4087

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