Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Molecular prevalence and clinical importance of Torque Teno Virus infection in Thalassemia Patients as high risk individuals

(2016) Molecular prevalence and clinical importance of Torque Teno Virus infection in Thalassemia Patients as high risk individuals. Biosciences Biotechnology Research Asia.

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Abstract

Recently a novel DNA virus (Torque Teno Virus (TTV) has been identified in Japan and shown to be associated with elevated aminotransferase s levels after transfusion. However the exact role of TTV in pathogenesis of liver disease is yet to be established. The purpose of this study was to determine the prevalence of TTV in thalassemic patients and its relationship with elevated alanine-aminotransfrase (ALT) and aspartateaminotransfrase (AST). This cross-sectional analysis study was conducted on 452 thallasemic patients. Serums were collected from all of the patients, first ALT and AST levels were determined. Then, after DNA extraction, TTV DNA was amplified and detected using semi-nested PCR, followed by gel electrophoresis. Demographic characteristics and clinical data were collected from each participant for statistical analysis. The findings showed that 160 of 452 (35.4) samples had TTV DNA detected by PCR. From 160 TTV DNA positive, 98 (61.20) were female and 62 (38.80) of them were male (P=0.549). The mean ALT and AST values in TTV positive group were higher than in TTV negative group, and the difference was statistically significant (p<0.0001). The result showed that the prevalence of TTV in thalassemic patients in Jahrom is less than other studies in Iran and the mean ALT and AST values in TTV positive individuals were about 2 times more than in TTV negative individuals.

Item Type: Article
Additional Information: cited By 1
Keywords: alanine aminotransferase; aspartate aminotransferase; virus DNA, age distribution; alanine aminotransferase blood level; Article; aspartate aminotransferase blood level; blood transfusion; child; controlled study; DNA extraction; female; high risk patient; human; Iran; major clinical study; male; nucleic acid amplification; prevalence; splenectomy; thalassemia; Torque teno virus 1; Torque teno virus infection; virus detection; virus transmission
Subjects: QW Microbiology and Immunology > QW 501-949 Immunology
Divisions: Research Vice-Chancellor Department > Social Determinants in Health Promotion Research Center
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/4058

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