Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Bioinformatics evaluation of the possibility of heat shock proteins as autoantigens in multiple sclerosis based on molecular mimicry hypothesis

(2016) Bioinformatics evaluation of the possibility of heat shock proteins as autoantigens in multiple sclerosis based on molecular mimicry hypothesis. Journal of Neuroimmunology.

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Abstract

Molecular mimicry is the explanatory link between the heat shock proteins (HSPs) of infectious agents and triggering multiple sclerosis. Considering that there are many similarities between self- and bacterial-HSPs, the goal was to investigate a panel of 60- and 70 kDa HSPs from a variety of bacteria in order to predict the role of each microorganism in triggering or progression of the disease under the molecular mimicry hypothesis. By clarifying the peptides meeting criteria for cross-reactivity and elucidating the role of each microorganism in MS pathogenesis, it would be easier to suggest more effective treatment and preventive strategies for this disease. © 2016 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Keywords: Autoimmunity; Heat shock proteins (HSPs); Immunoinformatics; Molecular mimicry; Multiple Sclerosis (MS)
Subjects: WD Disorders of Systemic, Metabolic or Environmental Origin, etc. > WD 300-380 Immunologic and Collagen Diseases. Hypersensitivity
Divisions: Research Vice-Chancellor Department > Social Determinants in Health Promotion Research Center
Depositing User: خانم الهه خسروی
URI: http://eprints.hums.ac.ir/id/eprint/4037

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