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Hormozgan University of Medical Sciences

Association between magnesium and cardiovascular disease risk: Systematic review and meta-analysis of cohort studies updated to July 2016

(2016) Association between magnesium and cardiovascular disease risk: Systematic review and meta-analysis of cohort studies updated to July 2016. International Journal of Pharmacy and Technology.

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Abstract

The cardiovascular disease is one of the most important reasons for death worldwide. Some studies have shown that magnesium can reduce the risk of cardiovascular diseases,but these studies do not have the similar results. Hence in this study we tried by doing a systematic review and meta-analysis to investigate the effect of magnesium intake through the drinking water and food as well as the serum level of magnesium on the pulmonary heart disease risk. For finding the studies conducted in Iran and the world,we used the databases Pubmed,Scopus,Irandoc,SID and ISI. 22 articles (23 cohort studies) inall of which an almost similar methodology had been used and all of them had been done in the time interval from 1995 up to 2016,were investigated. Heterogeneity of the studies was high both in adsorption studies (I2 = 62,p value = 0.002) and in the serum ones (I2= 51,p value = 0.029). Hence the random effect model was used for overall meta-analysis of studies. Meta-analysis of 13 intake studies showed there is not any significant relationship between magnesium intake through the water and food and the cardiovascular risk (RR = 0.91,95 CI (0.81-1.03),P value = 0.13). Meta-analysis of 10 cohort studies showed there is a significant relationship between the serum magnesium and the cardiovascular risk. An increase in serum magnesiumreduced significantly the cardiovascular risk by 27 (RR = 0.73,95 CI (0.64-0.84),P value < 0.001). Eggers’ testshowed there is no considerable release of error (p value < 0.001) in the intake studies (Intercept:-0.64,95 (-3.6,2.3) and serum studies (Intercept:-2.2,95 (-4.6,0.64). The results of this study supported the reduction of the risk of cardiovascular diseases resulting from an increase in serum level of magnesium (P value<0.001). © 2016,International Journal of Pharmacy and Technology. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Keywords: magnesium cardiovascular
Subjects: Cardiovascular System > WG 120-180 Cardiovascular Diseases, Diagnosis, and Therapeutics
Divisions: Research Vice-Chancellor Department > Food Health Research Center
Depositing User: مهندس هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/4013

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