Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Increased serum levels of IL-17A and IL-23 are associated with decreased vitamin D3 and increased pain in osteoarthritis

(2016) Increased serum levels of IL-17A and IL-23 are associated with decreased vitamin D3 and increased pain in osteoarthritis. PLoS ONE.

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Abstract

Introduction: Osteoarthritis (OA) is the most common type of arthritis and proinflammatory cytokines have been considered as the main etiologic factor in the pathogenesis of the disease. Serum levels of cytokines, that are associated with innate immunity and TH1 cells, have been analyzed in OA patients, however, there is limited research that profiles cytokines associated with Th17 cells and their relation to vitamin D3 and pain. Material and methods: The sera from 131 patients with OA and 262 healthy controls were evaluated for serum levels of IL-17A, IL-21, IL-23 and vitamin D3 using ELISA. Results: Serum levels of IL-17A, and IL-23 were statistically higher in OA patients than in healthy controls, while IL-21 and vitamin D3 were significantly lower in OA patients when compared to controls. A significant positive correlation was found between the serum levels of IL-17A and IL-23 using WOMAC pain scores and vitamin D3 serum levels. Discussion: The results suggest that IL-17A plays a significant role in OA pathogenesis and the induction of pain. Decreased serum levels of vitamin D3 may reflect a positive role played by the factor in the regulation of immune responses in OA patients. © Copyright 2016 Askari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Item Type: Article
Additional Information: cited By 2
Keywords: colecalciferol; interleukin 17; interleukin 23; colecalciferol; IL17A protein, human; interleukin 17; interleukin 21; interleukin 23; interleukin derivative, adult; Article; body mass; controlled study; cross-sectional study; disease association; female; human; Iranian people; major clinical study; male; middle aged; molecular pathology; osteoarthritis; pain; pain assessment; protein analysis; protein blood level; theWestern OntarioMcMaster University Osteoarthritis Index; vitamin blood level; blood; case control study; complication; osteoarthritis; pain, Adult; Case-Control Studies; Cholecalciferol; Cross-Sectional Studies; Female; Humans; Interleukin-17; Interleukin-23; Interleukins; Male; Osteoarthritis; Pain
Subjects: QT Physiology > QT34-37 Physics. Mathematics. Engineering
Divisions: Research Vice-Chancellor Department > Student Research Committee
Depositing User: هدی فهیم پور
URI: http://eprints.hums.ac.ir/id/eprint/3932

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