Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Association of Anti-Phosphatidylcholine Antibodies with Acute Myocardial Infarction: A Comparative Study

(2013) Association of Anti-Phosphatidylcholine Antibodies with Acute Myocardial Infarction: A Comparative Study. Association of Anti-Phosphatidylcholine Antibodies with Acute Myocardial Infarction: A Comparative Study.

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Abstract

Many factors play a role in Acute Myocardial Infarction (AMI). One those anti-Phospholipid (aPL) antibodies, that may act in the induction of immunological response leading to the development of AMI. Anti-Phosphatidylcholines (PC) antibody is detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study of anti-PC antibody in AMI might shed light on etiologic mechanisms in the pathogenesis of acute coronary syndromes. This study was designed to investigate whether prevalence of anti-PC antibodies, in patients who had AMI and to analyze their relationship with traditional cardiovascular risk factors. The prevalence of anti-PC IgG and IgM in a well characterized group of patients with AMI as a case group and in age and sex matched healthy subjects as control group. Sera from the case and the control groups were tested to evaluate the presence of IgG and IgM isotypes to anti-PC by ELISA method. The prevalence of anti-PC IgG and also IgM in the case group resulted significantly higher than in the control group with AMI (p<0.005). Our findings suggest that anti-PC antibodies seemed to play a role in AMI, independent risk factors for AMI, which may represent a link between autoimmunity and atherosclerosis in patients with AMI. Further studies with bigger sample size including patients with AMI and healthy people are needed to explore the exact role of anti-PC antibodies in AMI.

Item Type: Article
Keywords: Anti-Phosphatidylcholines (PC) Antibodies, Acute Myocardial Infarction (AMI), AntiPhospholipid (aPL) Antibodies, Cardiovascular Ischemia
Subjects: WA Public Health > WA 108-245 Preventive Medicine
Divisions: Research Vice-Chancellor Department > Social Determinants in Health Promotion Research Center
Depositing User: مركز تحقيقات عوامل اجتماعی درارتقا سلامت خليج فارس
URI: http://eprints.hums.ac.ir/id/eprint/3580

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