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Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Comparing the effects of mag- nesium sulphate and remifentanil on the hemodynamic responses after laryngoscopy and endotracheal intubation

(1393) Comparing the effects of mag- nesium sulphate and remifentanil on the hemodynamic responses after laryngoscopy and endotracheal intubation. مجله انجمن آنستزیولوژی و مراقبتهای ویژه ایران.

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Abstract

Introduction: The sympathetic component of the autonomic nervous system is activated as a response to laryngoscopy and endotracheal intubation causing an increase in blood pressure and heart rate. In patients with underlying cardiovascular disease these changes may cause acute cardiac ischemia accompanying significant morbidity and mortality. The purpose of this current study was to compare the effects of magnesium sulphate and remifentanil on hemodynamic responses following laryngoscopy and endotracheal intubation. Materials and methods: In this double blind clinical trial 90 patients 15-50 years old, ASA I-II, who underwent elective surgery were randomly assigned into three groups, control, remifentanil and magnesium sulphate. Group 1, the control group. Group 2: Patients received magnesium sulphate 0.1 g/kg IV thirty minutes before laryngoscopy and endotracheal intubation. Group 3: Patients received remifentanil 1µg/Kg IV two minutes before laryngoscopy and endotracheal intubation. Blood pressure and heart rate were recorded before induction of anaesthesia, and at one, three and five minutes following laryngoscopy and intubation. Results: Mean changes of systolic and diastolic blood pressure, and heart rate one and three minutes following laryngoscopy and intubation in the magnesium sulphate group and remifentanil group were significantly different from the control group. (P< 0.05) Conclusion: According to this study, the use of remifentanil and magnesium sulphate as premedication drugs before laryngoscopy and endotracheal intubation may effectively prevent rise of systolic and diastolic blood pressures and heart rate. Magnesium sulphate premedication did not control the hemodynamic parameters as effectively as remifentanil did; therefore we suggest using remifentanil as a premedication of choice in laryngoscopy and intubation.

Item Type: Article
Keywords: Laryngoscopy, Magnesium sulphate, Remifentanil
Subjects: anesthesia
Divisions: Research Vice-Chancellor Department > Anaesthesiology, Critical Care and Pain Management Research Center
Depositing User: مركز تحقيقات بیهوشی و مراقبتهای ویژه
URI: http://eprints.hums.ac.ir/id/eprint/3126

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