Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Research project #3058

(2014) مطالعه اثردمتیلاسیون مادهlycopene در بر بیان ژنهای کلیدی آپوپتوز در سرطان معده. completed.

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Title

The Study of demethylating effect of Lycopene on expression of pro-apoptotic genes in Stomach cancer

Abstract

Dietary and nutritional factors have been reported to have gene expression and genome modulating effects that may pertain to the development or prevention of certain cancers. For example, some epidemiological studies suggest that a diet rich in fruits and vegetables, including soy, may be associated with a decreased risk of breast and other cancers [1, 2, 3]. In some Asian populations consuming traditional high phytoestrogen diets, epidemiological data correlate diet with reduced incidence of hormone-responsive cancers, and Asian women usually exhibit higher urinary and plasma phytoestrogen levels than women in Western populations [4]. Cancer development may also be prevented in part by the induction of apoptosis, thereby eliminating potentially damaged cells [5] or by interactions with signal transduction pathways in tumor cells as recently shown for lycopene [6]. Several natural dietary compounds have been reported to alter the epigenetic and subsequent gene expression status of tumor suppressor or other cancer relevant genes. Genistein has also been observed to modulate DNA methylation patterns in vivo and in vitro. Gene silencing associated with aberrant promoter methylation has been suggested as an alternate pathway for development of cancer [7]. This form of epigenetic change contributes to tumor initiation and progression by transcriptional silencing of tumor-suppressor genes. Several genes have been shown to be epigenetically inactivated in a wide range of tumors [8] and most neoplasms show hypermethylation of one or more genes [9-11]. This has led to the concept of a 'hypermethylation profile' of tumors which could have potential clinical applications [12-13]. Mure and Rossman [2001] reported that a variety of antioxidant compounds, including lycopene, vitamin C, andvitamin E were effective antimutagens against the highlyelevated levels of spontaneous mutagenesis in mismatch repair hMLH1-deficient HCT116 nonpolyposis colon cancer cells [14].

Item Type: Research project
Subjects: gastrointestinal and hepatic
molecular Genetics
genetic
pharmacology
Divisions: Research Vice-Chancellor Department > Molecular Medicine Research Center
Depositing User: مرکز تحقیقات پزشکی مولکولی
URI: http://eprints.hums.ac.ir/id/eprint/3058

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