Repository of Research and Investigative Information

Repository of Research and Investigative Information

Hormozgan University of Medical Sciences

Thesis #2971

[error in script] (2003) بررسی نارسایی های کروموزومی در مبتلایان به سرطانهای خون حاد و مزمن بالغین در بیمارستان وابسته به دانشگاه علوم پزشکی شهید بهشتی. پایان نامه مقطع Doctoral.

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Abstract

Purpose:the prime purpose of thise investigation was is there any specific marker in our patient suffering from CML and ANLL isthere any specific non random chromosomal abnormality in our patient is there any polymorphisms of heterochromatin in chromosome 1, 9 and 16 in our leukemic patients the relation of chromosomal changes to the bgenesis and classification of ANLL the role of possible mutagenic carcinogenic agents METHODS:a conventional cytogenetic examination on bone marrow peripheral blood either sex was studied in order to detect clonal abnormalities by employing G-banding technique as well as methotrexate cell synchronization technique HIgh resolution. Also Barium Hydroxide Saline Gimsa [BSG method was introuduct to eliminate variations in C-segment length in chromisomes 1,9 and 16. the result of investigation have been statistically analysed. Results:Cytogenetic investiigations were performed in patients with various subtype of acute Non lymphocytic leukemia and patient with chronic Myeloid Leukemia (CML) at the time of diagnosis . the most common chromosome rearrangments among 33 evaluated patients with ANLL were t(15,17), t(8,21) and t(9,22)this study concluded that cigarette smoking may not be possibly the sole cause of leukemia and combination of cigarett smoking and certian other etiological factors may contribute towards the process of leukemia

Item Type: Thesis (Doctoral)
Thesis Type: Doctoral
Keywords: سرطان نارسایی های کروموزومی
Supervisor:
Supervisor NameEmail
موفق, زهراUNSPECIFIED
Advisor:
Advisor NameEmail
حاج‌فتحعلی, عباسUNSPECIFIED
عطاریان, حمیدUNSPECIFIED
اصفهانی, فاطمهUNSPECIFIED
Subjects: internal medicine
hematology oncology
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Departments of Clinical Sciences > Department of Internal
Depositing User: کتابخانه مرکزی دانشگاه علوم پزشکی هرمزگان
URI: http://eprints.hums.ac.ir/id/eprint/2971

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